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Abstract：
According to the 2020 global cancer data released by the World Cancer Research Fund (WCRF) International, gastric cancer (GC) is the fifth most common cancer worldwide, with yearly increasing incidence and the second-highest fatality rate in malignancies. Despite the contemporary ambiguous molecular mechanisms in GC pathogenesis, numerous in-depth studies have demonstrated that zinc finger proteins (ZFPs) are essential for the development and progression of GC. ZFPs are a class of transcription factors with finger-like domains that bind to Zn2+ extensively and participate in gene replication, cell differentiation and tumor development. In this review, we briefly outline the roles, molecular mechanisms and the latest advances in ZFPs in GC, including eight principal aspects, such as cell proliferation, epithelial-mesenchymal transition (EMT), invasion and metastasis, inflammation and immune infiltration, apoptosis, cell cycle, DNA methylation, cancer stem cells (CSCs) and drug resistance. Intriguingly, the myeloid zinc finger 1 (MZF1) possesses reversely dual roles in GC by promoting tumor proliferation or impeding cancer progression via apoptosis. Therefore, a thorough understanding of the molecular mechanism of ZFPs on GC progression will pave the solid way for screening the potentially effective diagnostic indicators, prognostic biomarkers and therapeutic targets of GC.
摘要：
根据世界癌症研究基金会（WCRF）国际发布的2020年全球癌症数据，胃癌（GC）是全球第五大最常见的癌症，发病率逐年增加，死亡率在恶性肿瘤中排名第二。尽管当代GC发病机制的分子机制不明确，大量深入的研究表明，锌指蛋白（ZFP）对于GC的发生和发展至关重要。ZFP是一类具有指状结构域的转录因子，广泛结合Zn2+并参与基因复制，细胞分化和肿瘤的发展。在这次审查中,我们简要概述了角色，分子机制和ZFP在GC中的最新进展，包括八个主要方面，如细胞增殖，上皮-间质转化（EMT），侵袭和转移，炎症和免疫浸润，凋亡，细胞周期,DNA甲基化，肿瘤干细胞（CSC）与耐药性。有趣的是，髓样锌指1（MZF1）在GC中具有促进肿瘤增殖或通过凋亡阻止癌症进展的双重作用。因此,深入了解ZFP对GC进展的分子机制将为筛选潜在有效的诊断指标铺平道路，GC的预后生物标志物和治疗靶标。
