PDF(Pubmed)
Abstract：
BACKGROUND: Oral cancers have limited diagnostic tools to aid clinical management. Current evidence indicates that alterations in hemidesmosomes, the adhesion complexes primarily involved in epithelial attachment to the basement membrane, are correlated to cancer phenotype for multiple cancers. This systematic review aimed to assess the experimental evidence for hemidesmosomal alterations, specifically in relation to oral potentially malignant disorders and oral squamous cell carcinomas.
METHODS: We conducted a systemic review to summarise the available literature on hemidesmosomal components and their role in oral pre-cancer and cancer. Relevant studies were retrieved from a comprehensive search of Scopus, Ovid MEDLINE, Ovid Embase and Web of Science.
RESULTS: 26 articles met the inclusion criteria, of which 19 were in vitro studies, 4 in vivo studies, 1 in vitro and in vivo study, and 2 in vitro and cohort studies. Among them, 15 studies discussed individual alpha-6 and/or beta-4 subunits, 12 studies discussed the alpha-6 beta-4 heterodimers, 6 studies discussed the entire hemidesmosome complex, 5 studies discussed bullous pemphigoid-180, 3 studies discussed plectin, 3 studies discussed bullous pemphigoid antigen-1 and 1 study discussed tetraspanin.
CONCLUSIONS: Heterogeneity in cell type, experimental models, and methods were observed. Alterations in hemidesmosomal components were shown to contribute to oral pre-cancer and cancer. We conclude that there is sufficient evidence for hemidesmosomes and their components to be potential biomarkers for evaluating oral carcinogenesis.
METHODS: We conducted a systemic review to summarise the available literature on hemidesmosomal components and their role in oral pre-cancer and cancer. Relevant studies were retrieved from a comprehensive search of Scopus, Ovid MEDLINE, Ovid Embase and Web of Science.
RESULTS: 26 articles met the inclusion criteria, of which 19 were in vitro studies, 4 in vivo studies, 1 in vitro and in vivo study, and 2 in vitro and cohort studies. Among them, 15 studies discussed individual alpha-6 and/or beta-4 subunits, 12 studies discussed the alpha-6 beta-4 heterodimers, 6 studies discussed the entire hemidesmosome complex, 5 studies discussed bullous pemphigoid-180, 3 studies discussed plectin, 3 studies discussed bullous pemphigoid antigen-1 and 1 study discussed tetraspanin.
CONCLUSIONS: Heterogeneity in cell type, experimental models, and methods were observed. Alterations in hemidesmosomal components were shown to contribute to oral pre-cancer and cancer. We conclude that there is sufficient evidence for hemidesmosomes and their components to be potential biomarkers for evaluating oral carcinogenesis.
摘要：
背景：口腔癌的诊断工具有限，无法帮助临床治疗。目前的证据表明半染色体的改变，粘附复合物主要参与上皮与基底膜的附着，与多种癌症的癌症表型相关。本系统综述旨在评估半上小脑改变的实验证据，特别是与口腔潜在恶性疾病和口腔鳞状细胞癌有关。
方法：我们进行了一项系统综述，以总结现有文献中关于半网状结构成分及其在口腔癌前病变和癌症中的作用。相关研究是从Scopus的全面搜索中检索到的，OvidMEDLINE,OvidEmbase和WebofScience。
结果：26篇文章符合纳入标准，其中19项是体外研究，4个体内研究，1体外和体内研究，和2个体外和队列研究。其中,15项研究讨论了单个α-6和/或β-4亚基，12项研究讨论了α-6β-4异二聚体，6项研究讨论了整个半结膜复合体，5项研究讨论了大疱性类天疱疮-180，3项研究讨论了plectin，3项研究讨论了大疱性类天疱疮抗原-1，1项研究讨论了四跨膜蛋白。
结论：细胞类型的异质性，实验模型，和方法进行了观察。半网间体成分的改变被证明有助于口腔癌前病变和癌症。我们得出的结论是，有足够的证据表明半染色体及其成分是评估口腔癌变的潜在生物标志物。
方法：我们进行了一项系统综述，以总结现有文献中关于半网状结构成分及其在口腔癌前病变和癌症中的作用。相关研究是从Scopus的全面搜索中检索到的，OvidMEDLINE,OvidEmbase和WebofScience。
结果：26篇文章符合纳入标准，其中19项是体外研究，4个体内研究，1体外和体内研究，和2个体外和队列研究。其中,15项研究讨论了单个α-6和/或β-4亚基，12项研究讨论了α-6β-4异二聚体，6项研究讨论了整个半结膜复合体，5项研究讨论了大疱性类天疱疮-180，3项研究讨论了plectin，3项研究讨论了大疱性类天疱疮抗原-1，1项研究讨论了四跨膜蛋白。
结论：细胞类型的异质性，实验模型，和方法进行了观察。半网间体成分的改变被证明有助于口腔癌前病变和癌症。我们得出的结论是，有足够的证据表明半染色体及其成分是评估口腔癌变的潜在生物标志物。
