PDF(Pubmed)
Abstract：
Structural airway changes related to chronic cough (CC) are described in the literature, but so far reported data are rare and non-conclusive. Furthermore, they derive mainly from cohorts with small sample sizes. Advanced CT imaging not only allows airway abnormalities to be quantified, but also to count the number of visible airways. The current study evaluates these airway abnormalities in CC and assesses the contribution of CC in addition to CT findings on the progression of airflow limitation, defined as a decline in forced expiratory volume in 1 s (FEV1) over time.
A total of 1183 males and females aged ≥40 years with thoracic CT scans and valid spirometry from Canadian Obstructive Lung Disease, a Canadian multicentre, population-based study has been included in this analysis. Participants were stratified into 286 never-smokers, 297 ever-smokers with normal lung function and 600 with chronic obstructive pulmonary disease (COPD) of different severity grades. Imaging parameters analyses included total airway count (TAC), airway wall thickness, emphysema as well as parameters for functional small airway disease quantification.
Irrespective of COPD presence, CC was not related to specific airway and lung structure features. Independent of TAC and emphysema score, CC was highly associated with FEV1 decline over time in the entire study population, particularly in ever-smokers (p<0.0001).
The absence of specific structural CT features independently from COPD presence indicate that other underlying mechanisms are contributing to the symptomatology of CC. On top of derived CT parameters, CC seems to be independently associated with FEV1 decline.
NCT00920348.
A total of 1183 males and females aged ≥40 years with thoracic CT scans and valid spirometry from Canadian Obstructive Lung Disease, a Canadian multicentre, population-based study has been included in this analysis. Participants were stratified into 286 never-smokers, 297 ever-smokers with normal lung function and 600 with chronic obstructive pulmonary disease (COPD) of different severity grades. Imaging parameters analyses included total airway count (TAC), airway wall thickness, emphysema as well as parameters for functional small airway disease quantification.
Irrespective of COPD presence, CC was not related to specific airway and lung structure features. Independent of TAC and emphysema score, CC was highly associated with FEV1 decline over time in the entire study population, particularly in ever-smokers (p<0.0001).
The absence of specific structural CT features independently from COPD presence indicate that other underlying mechanisms are contributing to the symptomatology of CC. On top of derived CT parameters, CC seems to be independently associated with FEV1 decline.
NCT00920348.
摘要：
背景：文献中描述了与慢性咳嗽（CC）相关的结构性气道变化，但到目前为止，报告的数据很少见，也没有定论。此外，它们主要来自样本量小的队列。先进的CT成像不仅可以量化气道异常，还要计算可见气道的数量。当前的研究评估了CC中的这些气道异常，并评估了CC以及CT对气流受限进展的影响。定义为随着时间的推移，强制呼气量（FEV1）在1s内下降。
方法：共有1183名年龄≥40岁的男性和女性接受了来自加拿大阻塞性肺病的胸部CT扫描和有效的肺活量测定，加拿大多中心，以人群为基础的研究已纳入本分析.参与者被分层为286名从不吸烟者，297例肺功能正常的吸烟者和600例不同严重程度的慢性阻塞性肺疾病（COPD）。成像参数分析包括总气道计数（TAC），气道壁厚,肺气肿以及功能性小气道疾病量化参数。
结果：无论是否存在COPD，CC与特定的气道和肺结构特征无关。与TAC和肺气肿评分无关，在整个研究人群中，CC与FEV1随时间下降高度相关，特别是在吸烟者中（p<0.0001）。
结论：不存在与COPD无关的特定结构CT特征表明，其他潜在机制也有助于CC的症状学。在导出的CT参数之上，CC似乎与FEV1下降独立相关。
背景：NCT00920348。
方法：共有1183名年龄≥40岁的男性和女性接受了来自加拿大阻塞性肺病的胸部CT扫描和有效的肺活量测定，加拿大多中心，以人群为基础的研究已纳入本分析.参与者被分层为286名从不吸烟者，297例肺功能正常的吸烟者和600例不同严重程度的慢性阻塞性肺疾病（COPD）。成像参数分析包括总气道计数（TAC），气道壁厚,肺气肿以及功能性小气道疾病量化参数。
结果：无论是否存在COPD，CC与特定的气道和肺结构特征无关。与TAC和肺气肿评分无关，在整个研究人群中，CC与FEV1随时间下降高度相关，特别是在吸烟者中（p<0.0001）。
结论：不存在与COPD无关的特定结构CT特征表明，其他潜在机制也有助于CC的症状学。在导出的CT参数之上，CC似乎与FEV1下降独立相关。
背景：NCT00920348。
