PDF(Pubmed)
Abstract：
OBJECTIVE: The purpose of this article was to review the association between the ETS-related gene (ERG) and the phosphatase and tensin homolog (PTEN) genes with pathologic parameters of prostate cancer, emphasizing on Gleason score.
METHODS: We performed a PubMed-based search of the literature emphasizing on articles that use pathological techniques, and especially on those that report the use immunohistochemical staining and FISH to investigate the association between ERG and PTEN mutations with the histopathologic parameters of prostate cancer.
RESULTS: ERG expression is frequently marked in patients with prostate cancer, usually due to the occurrence of the TMPRSS2:ERG gene fusion. Although some studies reported a potential link between the expression of ERG and Gleason score, there is no strong evidence supporting this finding. On the contrary, there is more solid evidence correlating loss of PTEN expression with worse prognosis and higher Gleason scores. Few studies correlate the over-expression of ERG gene with the loss of PTEN expression. Finally, PTEN and ERG have been studied as potential therapeutic targets, and several promising results have been reported.
CONCLUSIONS: Although, at some degree, ERG expression seems to be associated with the morphological features of prostate cancer, different studies reported controversial results. However, expression of PTEN is more clearly associated with the pathology and clinical course of the disease. More research is required to elucidate the role of these molecules in the molecular pathology of prostate cancer, as well as their potential use as therapeutic targets.
METHODS: We performed a PubMed-based search of the literature emphasizing on articles that use pathological techniques, and especially on those that report the use immunohistochemical staining and FISH to investigate the association between ERG and PTEN mutations with the histopathologic parameters of prostate cancer.
RESULTS: ERG expression is frequently marked in patients with prostate cancer, usually due to the occurrence of the TMPRSS2:ERG gene fusion. Although some studies reported a potential link between the expression of ERG and Gleason score, there is no strong evidence supporting this finding. On the contrary, there is more solid evidence correlating loss of PTEN expression with worse prognosis and higher Gleason scores. Few studies correlate the over-expression of ERG gene with the loss of PTEN expression. Finally, PTEN and ERG have been studied as potential therapeutic targets, and several promising results have been reported.
CONCLUSIONS: Although, at some degree, ERG expression seems to be associated with the morphological features of prostate cancer, different studies reported controversial results. However, expression of PTEN is more clearly associated with the pathology and clinical course of the disease. More research is required to elucidate the role of these molecules in the molecular pathology of prostate cancer, as well as their potential use as therapeutic targets.
摘要：
目的：本文的目的是综述ETS相关基因（ERG）和磷酸酶和张力蛋白同源物（PTEN）基因与前列腺癌病理参数之间的关系。强调格里森分数。
方法：我们进行了基于PubMed的文献搜索，强调使用病理技术的文章，尤其是那些报道使用免疫组织化学染色和FISH研究ERG和PTEN突变与前列腺癌组织病理学参数之间的关联的研究。
结果：在前列腺癌患者中经常有ERG表达，通常是由于TMPRSS2：ERG基因融合的发生。尽管一些研究报道了ERG的表达与Gleason评分之间的潜在联系，没有强有力的证据支持这一发现。相反,有更多确凿证据表明PTEN表达缺失与预后较差和Gleason评分较高相关.很少有研究将ERG基因的过表达与PTEN表达的丧失相关联。最后,PTEN和ERG已被研究为潜在的治疗靶点，和几个有希望的结果已经报道。
结论：虽然，在某种程度上,ERG的表达似乎与前列腺癌的形态学特征有关，不同的研究报告了有争议的结果。然而,PTEN的表达与疾病的病理和临床过程更明显地相关。需要更多的研究来阐明这些分子在前列腺癌的分子病理学中的作用，以及它们作为治疗靶点的潜在用途。
方法：我们进行了基于PubMed的文献搜索，强调使用病理技术的文章，尤其是那些报道使用免疫组织化学染色和FISH研究ERG和PTEN突变与前列腺癌组织病理学参数之间的关联的研究。
结果：在前列腺癌患者中经常有ERG表达，通常是由于TMPRSS2：ERG基因融合的发生。尽管一些研究报道了ERG的表达与Gleason评分之间的潜在联系，没有强有力的证据支持这一发现。相反,有更多确凿证据表明PTEN表达缺失与预后较差和Gleason评分较高相关.很少有研究将ERG基因的过表达与PTEN表达的丧失相关联。最后,PTEN和ERG已被研究为潜在的治疗靶点，和几个有希望的结果已经报道。
结论：虽然，在某种程度上,ERG的表达似乎与前列腺癌的形态学特征有关，不同的研究报告了有争议的结果。然而,PTEN的表达与疾病的病理和临床过程更明显地相关。需要更多的研究来阐明这些分子在前列腺癌的分子病理学中的作用，以及它们作为治疗靶点的潜在用途。
