PDF(Pubmed)
Abstract：
Acute gastrointestinal graft-versus-host disease (GI GVHD) is a complication after hematopoietic stem cell transplant with high morbidity and mortality. In particular, steroid-refractory GI GVHD can be difficult to treat. Recent investigations have revealed that patients after transplant can experience intestinal dysbiosis contributing to the progression of GVHD. Modulation of the gut microbiome through dietary intake could potentially improve the intestinal dysbiosis in GI GVHD. In this case series, we present 3 patients where dietary therapy was used in conjunction with immunosuppression to achieve clinical remission of GI GVHD.
摘要：
急性胃肠道移植物抗宿主病（GIGVHD）是造血干细胞移植后的并发症，具有很高的发病率和死亡率。特别是,类固醇难治性GIGVHD可能难以治疗。最近的研究表明，移植后的患者可能会经历肠道菌群失调，从而导致GVHD的进展。通过饮食摄入调节肠道微生物组可能会改善GIGVHD中的肠道生态失调。在这个系列中,我们介绍了3例患者的饮食治疗联合免疫抑制以实现GIGVHD的临床缓解。
