Abstract：
Multifunctional hydrogel dressings are promising for wound healing. In the study, chlorhexidine(CHX) loaded double network hydrogels were prepared by free radical polymerization of sulfobetaine and oxidative self-crosslinking of reduced keratin. The introduced keratin and CHX endowed hydrogels with cytocompatibility, antioxidant capability as well as enhanced antibacterial activity due to the antifouling property of polysulfobetaine. These hydrogels exhibited acidity, glutathione(GSH), and trypsin triple-responsive release behaviors, resulting in the accelerated release of CHX under wound microenvironments. Intriguingly, the freeze-drying hydrogels could be ground to powders and sprinkled on the irregular wound bed, followed by absorbing wound fluid to reform hydrogel in situ. These xerogel powders were more convenient for sterilization, formulation, and storage. Further, these xerogel powders could be rejected after being mixed with an appropriate amount of water. In vivo infected wound healing confirmed that the xerogel powder dressing significantly promoted collagen deposition and reduced inflammation, thereby accelerating the closure and regeneration of skin wounds. Taken together, these degradable xerogel powders have great potential applications for wound healing.
摘要：
多功能水凝胶敷料有望用于伤口愈合。在研究中,通过磺基甜菜碱的自由基聚合和还原角蛋白的氧化自交联制备了氯己定（CHX）负载的双网络水凝胶。引入的角蛋白和CHX赋予水凝胶细胞相容性，由于聚磺基甜菜碱的防污性，抗氧化能力以及增强的抗菌活性。这些水凝胶表现出酸度，谷胱甘肽(GSH),和胰蛋白酶三重反应释放行为，导致伤口微环境下CHX的加速释放。有趣的是，冷冻干燥的水凝胶可以被研磨成粉末并撒在不规则的伤口床上，然后吸收伤口流体以原位重整水凝胶。这些气凝胶粉末更便于灭菌，配方，和存储。Further,这些气凝胶粉末在与适量的水混合后可以被拒绝。体内感染伤口愈合证实，气凝胶粉末敷料显着促进胶原蛋白沉积和减少炎症，从而加速皮肤伤口的闭合和再生。一起来看,这些可降解气凝胶粉末在伤口愈合方面具有巨大的潜在应用。
