PDF(Pubmed)
Abstract：
UNASSIGNED: It is estimated that up to one third of COVID-19 patients can develop long-lasting smell dysfunction. Viral infections, especially COVID-19, can cause anosmia through different pathomechanisms, and different strategies have been proposed for effectively managing post-COVID-19 olfactory dysfunction in clinical practice, with olfactory training being recommended as a first-line treatment option.
UNASSIGNED: This report describes a non-consecutive series of clinical cases. After COVID-19, eight cases (5 females, 3 males) of adult patients with long-lasting (3+ months) post-viral smell dysfunction followed a 30-day olfactory training protocol with a set of plant-derived essential oils. At baseline and at the end of the treatment, the patients were administered the Assessment of Self-reported Olfactory Functioning (ASOF) questionnaire, an inventory used to measure olfactory dysfunction and health-related quality of life.
UNASSIGNED: For any of the outcomes assessed with the ASOF scale, a significant improvement from baseline was reported, even though mean value ameliorations were more pronounced for olfactory function per se (Subjective Olfactory Capability: from 3.6 to 5.6 out of 10; Self-Reported capability of Perceiving specific odors: from 1.8 to 3.0 out of 5), rather than for health-related quality of life (Olfactory-Related Quality of life: from 2.9 to 3.9 out of 6).
UNASSIGNED: It was observed that patients with long-lasting COVID-19-related smell dysfunction improved after a 30-day olfactory training protocol. Further controlled clinical studies would be useful to better investigate the role of olfactory training in patients with postviral smell dysfunction.
UNASSIGNED: This report describes a non-consecutive series of clinical cases. After COVID-19, eight cases (5 females, 3 males) of adult patients with long-lasting (3+ months) post-viral smell dysfunction followed a 30-day olfactory training protocol with a set of plant-derived essential oils. At baseline and at the end of the treatment, the patients were administered the Assessment of Self-reported Olfactory Functioning (ASOF) questionnaire, an inventory used to measure olfactory dysfunction and health-related quality of life.
UNASSIGNED: For any of the outcomes assessed with the ASOF scale, a significant improvement from baseline was reported, even though mean value ameliorations were more pronounced for olfactory function per se (Subjective Olfactory Capability: from 3.6 to 5.6 out of 10; Self-Reported capability of Perceiving specific odors: from 1.8 to 3.0 out of 5), rather than for health-related quality of life (Olfactory-Related Quality of life: from 2.9 to 3.9 out of 6).
UNASSIGNED: It was observed that patients with long-lasting COVID-19-related smell dysfunction improved after a 30-day olfactory training protocol. Further controlled clinical studies would be useful to better investigate the role of olfactory training in patients with postviral smell dysfunction.
摘要：
■据估计，多达三分之一的COVID-19患者会出现持久的嗅觉功能障碍。病毒感染,特别是COVID-19，可以通过不同的病理机制引起失语症，并在临床实践中提出了有效管理COVID-19后嗅觉功能障碍的不同策略，嗅觉训练被推荐为一线治疗选择。
■本报告描述了一系列非连续的临床病例。COVID-19后，8例(5例女性，3名男性）患有长期（3个月以上）病毒后气味功能障碍的成年患者遵循了30天的嗅觉训练方案，其中包括一组植物来源的精油。在基线和治疗结束时，患者接受了自我报告嗅觉功能评估(ASOF)问卷，用于测量嗅觉功能障碍和健康相关生活质量的清单。
■对于使用ASOF量表评估的任何结果，与基线相比有显著改善，即使嗅觉功能本身的均值改善更为明显（主观嗅觉能力：10分中的3.6至5.6；感知特定气味的自我报告能力：5分中的1.8至3.0），而不是与健康相关的生活质量（嗅觉相关的生活质量：6个中的2.9到3.9个）。
■观察到，患有与COVID-19相关的长期嗅觉功能障碍的患者在30天的嗅觉训练方案后有所改善。进一步的对照临床研究将有助于更好地研究嗅觉训练在病毒后嗅觉功能障碍患者中的作用。
■本报告描述了一系列非连续的临床病例。COVID-19后，8例(5例女性，3名男性）患有长期（3个月以上）病毒后气味功能障碍的成年患者遵循了30天的嗅觉训练方案，其中包括一组植物来源的精油。在基线和治疗结束时，患者接受了自我报告嗅觉功能评估(ASOF)问卷，用于测量嗅觉功能障碍和健康相关生活质量的清单。
■对于使用ASOF量表评估的任何结果，与基线相比有显著改善，即使嗅觉功能本身的均值改善更为明显（主观嗅觉能力：10分中的3.6至5.6；感知特定气味的自我报告能力：5分中的1.8至3.0），而不是与健康相关的生活质量（嗅觉相关的生活质量：6个中的2.9到3.9个）。
■观察到，患有与COVID-19相关的长期嗅觉功能障碍的患者在30天的嗅觉训练方案后有所改善。进一步的对照临床研究将有助于更好地研究嗅觉训练在病毒后嗅觉功能障碍患者中的作用。
