Abstract：
Early preeclampsia is associated with significant placental hypoperfusion. We explore the diagnostic value of placental diffusion-derived vessel density (DDVD), a biomarker derived from diffusion-weighted magnetic resonance imaging, which measures in vivo vessel microperfusion, in the differential diagnosis of normal and early preeclampsia pregnancies.
This was a prospective study involving 29 controls and 17 singleton pregnancies affected by early preeclampsia. Nineteen pregnancies from 28 to 34 weeks of gestational age were included from the normal group for a comparison with the early preeclampsia group. Using a 3.0 T magnetic resonance imaging scanner, diffusion-weighted images were obtained with the diffusion weighting b values of 0, 20, and 40 s/mm2. DDVDmean was the mean of DDVDb0b20 and DDVDb0b40, while DDVDb0b20 and DDVDb0b40 refer to the diffusion-derived vessel density values computed from b=0 and 20 s/mm2 images, and from b=0 and 40 s/mm2 images, respectively. The correlation between DDVDmean and gestational age was examined using a linear regression model. The area under the curve of the DDVDmean for early preeclampsia pregnancies detection was calculated by the receiver operating characteristic analysis.
As gestational age increased, DDVDmean linearly decreased. DDVDmean was significantly decreased in the early preeclampsia pregnancies compared with the normal pregnancies (52.72±46.73 versus 213.34±93.50 au/pixel; P<0.001). The area under the curve (DDVDmean) for discriminating between normal and early preeclampsia pregnancies regardless of fetal growth restriction was 0.954, and the area under the curve was 1.000 when early preeclampsia pregnancies without fetal growth restriction were excluded.
DDVDmean, an in vivo vessel microperfusion measure, allowed total separation of normal and early preeclampsia pregnancies.
This was a prospective study involving 29 controls and 17 singleton pregnancies affected by early preeclampsia. Nineteen pregnancies from 28 to 34 weeks of gestational age were included from the normal group for a comparison with the early preeclampsia group. Using a 3.0 T magnetic resonance imaging scanner, diffusion-weighted images were obtained with the diffusion weighting b values of 0, 20, and 40 s/mm2. DDVDmean was the mean of DDVDb0b20 and DDVDb0b40, while DDVDb0b20 and DDVDb0b40 refer to the diffusion-derived vessel density values computed from b=0 and 20 s/mm2 images, and from b=0 and 40 s/mm2 images, respectively. The correlation between DDVDmean and gestational age was examined using a linear regression model. The area under the curve of the DDVDmean for early preeclampsia pregnancies detection was calculated by the receiver operating characteristic analysis.
As gestational age increased, DDVDmean linearly decreased. DDVDmean was significantly decreased in the early preeclampsia pregnancies compared with the normal pregnancies (52.72±46.73 versus 213.34±93.50 au/pixel; P<0.001). The area under the curve (DDVDmean) for discriminating between normal and early preeclampsia pregnancies regardless of fetal growth restriction was 0.954, and the area under the curve was 1.000 when early preeclampsia pregnancies without fetal growth restriction were excluded.
DDVDmean, an in vivo vessel microperfusion measure, allowed total separation of normal and early preeclampsia pregnancies.
摘要：
背景：早期子痫前期与显著的胎盘灌注不足有关。我们探讨胎盘弥散源性血管密度的诊断价值，来自扩散加权磁共振成像的生物标志物，测量体内血管微灌注，在正常和早期子痫前期妊娠的鉴别诊断中。
方法：这是一项前瞻性研究，涉及29名对照和17名受早期先兆子痫影响的单胎妊娠。与早期先兆子痫组相比，正常组包括19例28至34周孕龄的妊娠。使用3.0T磁共振成像扫描仪，获得的扩散加权图像的扩散加权b值为0、20和40s/mm2。DDVDmean是DDVDb0b20和DDVDb0b40的平均值，而DDVDb0b20和DDVDb0b40是指从b=0和20s/mm2图像计算的扩散衍生血管密度值，从b=0和40s/mm2的图像，分别。使用线性回归模型检查DDVDmean与胎龄之间的相关性。通过接受者工作特性分析计算早期先兆子痫妊娠检测的DDVDmean曲线下面积。
结果：随着胎龄的增加，DDVDmean线性下降。与正常妊娠相比，子痫前期早期妊娠DDVDmean显着降低（52.72±46.73对213.34±93.50au/pixel；P<0.001）。无论胎儿生长受限，区分正常和早期先兆子痫妊娠的曲线下面积（DDVDmean）为0.954，当排除无胎儿生长受限的早期先兆子痫妊娠时，曲线下面积为1.000。
结论：DDVDmean，体内血管微灌注测量，允许正常和早期先兆子痫妊娠完全分离。
方法：这是一项前瞻性研究，涉及29名对照和17名受早期先兆子痫影响的单胎妊娠。与早期先兆子痫组相比，正常组包括19例28至34周孕龄的妊娠。使用3.0T磁共振成像扫描仪，获得的扩散加权图像的扩散加权b值为0、20和40s/mm2。DDVDmean是DDVDb0b20和DDVDb0b40的平均值，而DDVDb0b20和DDVDb0b40是指从b=0和20s/mm2图像计算的扩散衍生血管密度值，从b=0和40s/mm2的图像，分别。使用线性回归模型检查DDVDmean与胎龄之间的相关性。通过接受者工作特性分析计算早期先兆子痫妊娠检测的DDVDmean曲线下面积。
结果：随着胎龄的增加，DDVDmean线性下降。与正常妊娠相比，子痫前期早期妊娠DDVDmean显着降低（52.72±46.73对213.34±93.50au/pixel；P<0.001）。无论胎儿生长受限，区分正常和早期先兆子痫妊娠的曲线下面积（DDVDmean）为0.954，当排除无胎儿生长受限的早期先兆子痫妊娠时，曲线下面积为1.000。
结论：DDVDmean，体内血管微灌注测量，允许正常和早期先兆子痫妊娠完全分离。
