Abstract：
Obesity and visceral fat have been implicated as potential factors in the pathogenesis of the ossification of the posterior longitudinal ligament (OPLL); the details of the factors involved in OPLL remain unclear.
We aimed to determine the association between dyslipidemia and symptomatic OPLL.
Single institution cross-sectional study.
Data were collected from Japanese patients with OPLL (n=92) who underwent whole-spine computed tomography scanning. Control data (n=246) without any spinal ligament ossification were collected from 627 Japanese participants who underwent physical examination.
Baseline information and lipid parameters, including triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) from fasting blood samples were collected to assess the comorbidity of dyslipidemia.
Patient data were collected from 2020 to 2022. Patients with dyslipidemia were defined as those who were taking medication for dyslipidemia and who met one of the following criteria: TG ≥150 mg/dL, LDL-C ≥140 mg/dL, and/or HDL-C <40 mg/dL. The factors associated with OPLL development were evaluated using multivariate logistic regression analysis.
The comorbidity of dyslipidemia in the OPLL group was more than twice that in the control group (71.7% and 35.4%, respectively). The mean body mass index (BMI) of the OPLL group was significantly higher than that of the control group (27.2 kg/m2 and 23.0 kg/m2). Multivariate logistic regression analysis revealed that dyslipidemia was associated with the development of OPLL (regression coefficient, 0.80; 95% confidence interval, 0.11-1.50). Additional risk factors included age, BMI, and diabetes mellitus.
We demonstrated a novel association between dyslipidemia and symptomatic OPLL development using serum data. This suggests that visceral fat obesity or abnormal lipid metabolism are associated with the mechanisms of onset and exacerbation of OPLL as well as focal mechanical irritation due to being overweight.
We aimed to determine the association between dyslipidemia and symptomatic OPLL.
Single institution cross-sectional study.
Data were collected from Japanese patients with OPLL (n=92) who underwent whole-spine computed tomography scanning. Control data (n=246) without any spinal ligament ossification were collected from 627 Japanese participants who underwent physical examination.
Baseline information and lipid parameters, including triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) from fasting blood samples were collected to assess the comorbidity of dyslipidemia.
Patient data were collected from 2020 to 2022. Patients with dyslipidemia were defined as those who were taking medication for dyslipidemia and who met one of the following criteria: TG ≥150 mg/dL, LDL-C ≥140 mg/dL, and/or HDL-C <40 mg/dL. The factors associated with OPLL development were evaluated using multivariate logistic regression analysis.
The comorbidity of dyslipidemia in the OPLL group was more than twice that in the control group (71.7% and 35.4%, respectively). The mean body mass index (BMI) of the OPLL group was significantly higher than that of the control group (27.2 kg/m2 and 23.0 kg/m2). Multivariate logistic regression analysis revealed that dyslipidemia was associated with the development of OPLL (regression coefficient, 0.80; 95% confidence interval, 0.11-1.50). Additional risk factors included age, BMI, and diabetes mellitus.
We demonstrated a novel association between dyslipidemia and symptomatic OPLL development using serum data. This suggests that visceral fat obesity or abnormal lipid metabolism are associated with the mechanisms of onset and exacerbation of OPLL as well as focal mechanical irritation due to being overweight.
摘要：
背景：肥胖和内脏脂肪被认为是后纵韧带骨化（OPLL）发病的潜在因素；OPLL相关因素的细节仍不清楚。
目的：我们旨在确定血脂异常与症状性OPLL之间的关联。
方法：单机构横断面研究。
方法：数据来自接受全脊柱计算机断层扫描的日本OPLL患者（n=92）。没有任何脊柱韧带骨化的对照数据（n=246）是从627名接受体检的日本参与者中收集的。
方法：基线信息和血脂参数，包括甘油三酯（TG），高密度脂蛋白胆固醇（HDL-C），从空腹血液样本中收集低密度脂蛋白胆固醇（LDL-C）以评估血脂异常的共病。
方法：收集了2020年至2022年的患者数据。血脂异常患者定义为正在服用血脂异常药物并符合以下标准之一的患者：TG≥150mg/dL，LDL-C≥140mg/dL，和/或HDL-C<40mg/dL。使用多变量逻辑回归分析评估与OPLL发展相关的因素。
结果：OPLL组的血脂异常合并症是对照组的两倍多（71.7％和35.4％，分别)。OPLL组的平均体重指数（BMI）显着高于对照组（27.2kg/m2和23.0kg/m2）。多因素logistic回归分析显示血脂异常与OPLL的发展相关(回归系数,0.80；95%置信区间，0.11-1.50）。其他风险因素包括年龄，BMI,和糖尿病。
结论：我们使用血清数据证明了血脂异常与症状性OPLL发展之间的新关联。这表明内脏脂肪肥胖或异常的脂质代谢与OPLL的发作和恶化机制以及由于超重引起的局灶性机械刺激有关。
目的：我们旨在确定血脂异常与症状性OPLL之间的关联。
方法：单机构横断面研究。
方法：数据来自接受全脊柱计算机断层扫描的日本OPLL患者（n=92）。没有任何脊柱韧带骨化的对照数据（n=246）是从627名接受体检的日本参与者中收集的。
方法：基线信息和血脂参数，包括甘油三酯（TG），高密度脂蛋白胆固醇（HDL-C），从空腹血液样本中收集低密度脂蛋白胆固醇（LDL-C）以评估血脂异常的共病。
方法：收集了2020年至2022年的患者数据。血脂异常患者定义为正在服用血脂异常药物并符合以下标准之一的患者：TG≥150mg/dL，LDL-C≥140mg/dL，和/或HDL-C<40mg/dL。使用多变量逻辑回归分析评估与OPLL发展相关的因素。
结果：OPLL组的血脂异常合并症是对照组的两倍多（71.7％和35.4％，分别)。OPLL组的平均体重指数（BMI）显着高于对照组（27.2kg/m2和23.0kg/m2）。多因素logistic回归分析显示血脂异常与OPLL的发展相关(回归系数,0.80；95%置信区间，0.11-1.50）。其他风险因素包括年龄，BMI,和糖尿病。
结论：我们使用血清数据证明了血脂异常与症状性OPLL发展之间的新关联。这表明内脏脂肪肥胖或异常的脂质代谢与OPLL的发作和恶化机制以及由于超重引起的局灶性机械刺激有关。
