Abstract：
It is documented that osteoarthritis can promote the progression of breast cancer (BC).
This study aims to search for the essential genes associated with breast cancer (BC) and osteoarthritis (OA), explore the relationship between epithelial-mesenchymal transition (EMT)- related genes and the two diseases, and identify the candidate drugs.
The genes related to both BC and OA were determined by text mining. Protein-protein Interaction (PPI) analysis was carried out, and as a result, the exported genes were found to be related to EMT. PPI and the correlation of mRNA of these genes were also analyzed. Different kinds of enrichment analyses were performed on these genes. A prognostic analysis was performed on these genes for examining their expression levels at different pathological stages, in different tissues, and in different immune cells. Drug-gene interaction database was employed for potential drug discovery.
A total number of 1422 genes were identified as common to BC and OA and 58 genes were found to be related to EMT. We found that HDAC2 and TGFBR1 were significantly poor in overall survival. High expression of HDAC2 plays a vital role in the increase of pathological stages. Four immune cells might play a role in this process. Fifty-seven drugs were identified that could potentially have therapeutic effects.
EMT may be one of the mechanisms by which OA affects BC. Using the drugs can have potential therapeutic effects, which may benefit patients with both diseases and broaden the indications for drug use.
This study aims to search for the essential genes associated with breast cancer (BC) and osteoarthritis (OA), explore the relationship between epithelial-mesenchymal transition (EMT)- related genes and the two diseases, and identify the candidate drugs.
The genes related to both BC and OA were determined by text mining. Protein-protein Interaction (PPI) analysis was carried out, and as a result, the exported genes were found to be related to EMT. PPI and the correlation of mRNA of these genes were also analyzed. Different kinds of enrichment analyses were performed on these genes. A prognostic analysis was performed on these genes for examining their expression levels at different pathological stages, in different tissues, and in different immune cells. Drug-gene interaction database was employed for potential drug discovery.
A total number of 1422 genes were identified as common to BC and OA and 58 genes were found to be related to EMT. We found that HDAC2 and TGFBR1 were significantly poor in overall survival. High expression of HDAC2 plays a vital role in the increase of pathological stages. Four immune cells might play a role in this process. Fifty-seven drugs were identified that could potentially have therapeutic effects.
EMT may be one of the mechanisms by which OA affects BC. Using the drugs can have potential therapeutic effects, which may benefit patients with both diseases and broaden the indications for drug use.
摘要：
背景：据报道，骨关节炎可以促进乳腺癌（BC）的进展。
目的：本研究旨在寻找与乳腺癌（BC）和骨关节炎（OA）相关的必需基因，探讨上皮间质转化(EMT)相关基因与两种疾病的关系,并确定候选药物。
方法：通过文本挖掘确定与BC和OA相关的基因。进行蛋白质-蛋白质相互作用(PPI)分析,结果，发现输出的基因与EMT有关。并分析了PPI与这些基因mRNA的相关性。对这些基因进行了不同种类的富集分析。对这些基因进行了预后分析，以检查它们在不同病理阶段的表达水平。在不同的组织中，和不同的免疫细胞。药物-基因相互作用数据库用于潜在的药物发现。
结果：总共有1422个基因被鉴定为BC和OA共有，58个基因与EMT相关。我们发现HDAC2和TGFBR1在总生存期中显著较差。HDAC2的高表达在病理分期的增加中起着至关重要的作用。四种免疫细胞可能在这个过程中发挥作用。确定了57种可能具有潜在治疗作用的药物。
结论：EMT可能是OA影响BC的机制之一。使用这些药物可以有潜在的治疗效果，这可能使两种疾病的患者受益，并扩大药物使用的指征。
目的：本研究旨在寻找与乳腺癌（BC）和骨关节炎（OA）相关的必需基因，探讨上皮间质转化(EMT)相关基因与两种疾病的关系,并确定候选药物。
方法：通过文本挖掘确定与BC和OA相关的基因。进行蛋白质-蛋白质相互作用(PPI)分析,结果，发现输出的基因与EMT有关。并分析了PPI与这些基因mRNA的相关性。对这些基因进行了不同种类的富集分析。对这些基因进行了预后分析，以检查它们在不同病理阶段的表达水平。在不同的组织中，和不同的免疫细胞。药物-基因相互作用数据库用于潜在的药物发现。
结果：总共有1422个基因被鉴定为BC和OA共有，58个基因与EMT相关。我们发现HDAC2和TGFBR1在总生存期中显著较差。HDAC2的高表达在病理分期的增加中起着至关重要的作用。四种免疫细胞可能在这个过程中发挥作用。确定了57种可能具有潜在治疗作用的药物。
结论：EMT可能是OA影响BC的机制之一。使用这些药物可以有潜在的治疗效果，这可能使两种疾病的患者受益，并扩大药物使用的指征。
