PDF(Pubmed)
Abstract：
BACKGROUND: Laryngotracheoesophageal cleft (LTEC) is a rare disease in which the larynx and trachea communicate posteriorly to the esophagus. It is often associated with other congenital malformations, particularly gastrointestinal anomalies. Herein, we report a case of LTEC associated with a gastric polypoid lesion in bronchial tissue.
METHODS: A gastric mass was detected in a male fetus since week 21 of gestation using fetal ultrasonography. Esophagogastroduodenoscopy performed after birth revealed a pedunculated polypoid lesion of the gastric fornix. The patient experienced frequent vomiting and aspiration pneumonia, which persisted after nasoduodenal tube feeding. Communication between the airway and esophagus was suspected. Laryngoscopy performed 30 days later revealed an LTEC (type III). Partial gastrectomy was performed when the patient was 93 days of age. Histopathological examination revealed tumor consisting of cartilage tissue covered with a layer of respiratory epithelium.
CONCLUSIONS: The gastric tumor associated with LTEC exhibited structures mimicking bronchial tissue. LTEC occurs because of foregut maldevelopment, and the tumorous respiratory tissue in the stomach may have been formed from the same abnormal foregut development event as LTEC.
METHODS: A gastric mass was detected in a male fetus since week 21 of gestation using fetal ultrasonography. Esophagogastroduodenoscopy performed after birth revealed a pedunculated polypoid lesion of the gastric fornix. The patient experienced frequent vomiting and aspiration pneumonia, which persisted after nasoduodenal tube feeding. Communication between the airway and esophagus was suspected. Laryngoscopy performed 30 days later revealed an LTEC (type III). Partial gastrectomy was performed when the patient was 93 days of age. Histopathological examination revealed tumor consisting of cartilage tissue covered with a layer of respiratory epithelium.
CONCLUSIONS: The gastric tumor associated with LTEC exhibited structures mimicking bronchial tissue. LTEC occurs because of foregut maldevelopment, and the tumorous respiratory tissue in the stomach may have been formed from the same abnormal foregut development event as LTEC.
摘要：
背景：喉气管食管裂（LTEC）是一种罕见的疾病，其中喉和气管向后与食道相通。它通常与其他先天性畸形有关，尤其是肠胃异常.在这里，我们报告一例LTEC与支气管组织中的胃息肉样病变相关。
方法：使用胎儿超声检查从妊娠21周开始在男性胎儿中检测到胃肿块。出生后进行的食管胃十二指肠镜检查显示胃穹窿有蒂息肉样病变。病人出现频繁呕吐及吸入性肺炎,鼻十二指肠管喂养后持续存在。怀疑气道和食道之间的通讯。30天后进行的喉镜检查显示为LTEC（III型）。当患者93日龄时进行部分胃切除术。组织病理学检查显示肿瘤由覆盖有一层呼吸上皮的软骨组织组成。
结论：与LTEC相关的胃肿瘤表现出模拟支气管组织的结构。LTEC的发生是由于前肠发育不良，胃中的肿瘤呼吸组织可能是由与LTEC相同的异常前肠发育事件形成的。
方法：使用胎儿超声检查从妊娠21周开始在男性胎儿中检测到胃肿块。出生后进行的食管胃十二指肠镜检查显示胃穹窿有蒂息肉样病变。病人出现频繁呕吐及吸入性肺炎,鼻十二指肠管喂养后持续存在。怀疑气道和食道之间的通讯。30天后进行的喉镜检查显示为LTEC（III型）。当患者93日龄时进行部分胃切除术。组织病理学检查显示肿瘤由覆盖有一层呼吸上皮的软骨组织组成。
结论：与LTEC相关的胃肿瘤表现出模拟支气管组织的结构。LTEC的发生是由于前肠发育不良，胃中的肿瘤呼吸组织可能是由与LTEC相同的异常前肠发育事件形成的。
