PDF(Pubmed)
Abstract：
UNASSIGNED: We investigate the relationship between the changes of serum 25-hydroxyvitamin D3 (25(OH)D3) and vasohibin-1 (VASH-1) and renal function injury in patients with type 2 diabetic nephropathy.
UNASSIGNED: In this study, 143 patients with diabetic nephropathy (DN) were selected as DN group, and 80 patients with type 2 diabetes mellitus were selected as T2DM group. The serum 25 (OH) D3, VASH-1, blood glucose index, inflammation index and renal function index were compared between the two groups. According to the urinary microalbumin/creatinine ratio (UACR), the DN group was divided into microalbuminuria group (UACR range≥30.0mg/g and <300.0mg/g) and macroalbuminuria group (UACR≥300.0mg/g) for stratified comparison. The correlation between 25-hydroxyvitamin D3, VASH-1 and inflammation index and renal function index was analyzed by simple linear correlation analysis.
UNASSIGNED: The level of 25 (OH) D3 in DN group was significantly lower than that in T2DM group (P<0.05). The levels of VASH-1, CysC, BUN, Scr, 24h urine protein, serum CRP, TGF-β1, TNF-α and IL-6 in DN group were higher than those in T2DM group (P<0.05). The level of 25 (OH) D3 in DN patients with massive proteinuria was significantly lower than that in DN patients with microalbuminuria. The level of VASH-1 in DN patients with massive proteinuria was higher than that in DN patients with microalbuminuria (P<0.05). There was a negative correlation between 25 (OH) D3 and CysC, BUN, Scr, 24h urine protein, CRP, TGF-β1, TNF-α, IL-6 in patients with DN (P<0.05). VASH-1 was positively correlated with Scr, 24h urinary protein, CRP, TGF-β1, TNF-α and IL-6 in patients with DN (P<0.05).
UNASSIGNED: The level of serum 25 (OH) D3 in DN patients was considerably decreased, and the level of VASH-1 was increased, which was related to the degree of renal function injury and inflammatory response.
UNASSIGNED: In this study, 143 patients with diabetic nephropathy (DN) were selected as DN group, and 80 patients with type 2 diabetes mellitus were selected as T2DM group. The serum 25 (OH) D3, VASH-1, blood glucose index, inflammation index and renal function index were compared between the two groups. According to the urinary microalbumin/creatinine ratio (UACR), the DN group was divided into microalbuminuria group (UACR range≥30.0mg/g and <300.0mg/g) and macroalbuminuria group (UACR≥300.0mg/g) for stratified comparison. The correlation between 25-hydroxyvitamin D3, VASH-1 and inflammation index and renal function index was analyzed by simple linear correlation analysis.
UNASSIGNED: The level of 25 (OH) D3 in DN group was significantly lower than that in T2DM group (P<0.05). The levels of VASH-1, CysC, BUN, Scr, 24h urine protein, serum CRP, TGF-β1, TNF-α and IL-6 in DN group were higher than those in T2DM group (P<0.05). The level of 25 (OH) D3 in DN patients with massive proteinuria was significantly lower than that in DN patients with microalbuminuria. The level of VASH-1 in DN patients with massive proteinuria was higher than that in DN patients with microalbuminuria (P<0.05). There was a negative correlation between 25 (OH) D3 and CysC, BUN, Scr, 24h urine protein, CRP, TGF-β1, TNF-α, IL-6 in patients with DN (P<0.05). VASH-1 was positively correlated with Scr, 24h urinary protein, CRP, TGF-β1, TNF-α and IL-6 in patients with DN (P<0.05).
UNASSIGNED: The level of serum 25 (OH) D3 in DN patients was considerably decreased, and the level of VASH-1 was increased, which was related to the degree of renal function injury and inflammatory response.
摘要：
■探讨2型糖尿病肾病患者血清25-羟维生素D3(25(OH)D3)和血管抑制素-1(VASH-1)的变化与肾功能损伤的关系。
■在这项研究中，选择糖尿病肾病(DN)患者143例作为DN组,选取80例2型糖尿病患者作为T2DM组。血清25(OH)D3、VASH-1、血糖指数、比较两组患者的炎症指标和肾功能指标。根据尿微量白蛋白/肌酐比值（UACR），将DN组分为微量白蛋白尿组(UACR范围≥30.0mg/g和<300.0mg/g)和大量白蛋白尿组(UACR≥300.0mg/g)进行分层比较.采用简单线性相关分析25-羟维生素D3、VASH-1与炎症指标、肾功能指标的相关性。
■DN组25(OH)D3水平明显低于T2DM组(P<0.05)。VASH-1，CysC，BUN,Scr,24h尿蛋白，血清CRP,DN组TGF-β1、TNF-α、IL-6水平高于T2DM组(P<0.05)。大量蛋白尿的DN患者的25（OH）D3水平明显低于微量白蛋白尿的DN患者。大量蛋白尿的DN患者VASH-1水平高于微量白蛋白尿的DN患者（P<0.05）。25(OH)D3与CysC呈负相关,BUN,Scr,24h尿蛋白，CRP,TGF-β1,TNF-α,IL-6在DN患者中的表达(P<0.05)。VASH-1与Scr呈正相关,24h尿蛋白,CRP,TGF-β1、TNF-α和IL-6在DN患者中的表达(P<0.05)。
■DN患者血清25(OH)D3水平明显下降,VASH-1的水平提高了，与肾功能损伤程度及炎症反应有关。
■在这项研究中，选择糖尿病肾病(DN)患者143例作为DN组,选取80例2型糖尿病患者作为T2DM组。血清25(OH)D3、VASH-1、血糖指数、比较两组患者的炎症指标和肾功能指标。根据尿微量白蛋白/肌酐比值（UACR），将DN组分为微量白蛋白尿组(UACR范围≥30.0mg/g和<300.0mg/g)和大量白蛋白尿组(UACR≥300.0mg/g)进行分层比较.采用简单线性相关分析25-羟维生素D3、VASH-1与炎症指标、肾功能指标的相关性。
■DN组25(OH)D3水平明显低于T2DM组(P<0.05)。VASH-1，CysC，BUN,Scr,24h尿蛋白，血清CRP,DN组TGF-β1、TNF-α、IL-6水平高于T2DM组(P<0.05)。大量蛋白尿的DN患者的25（OH）D3水平明显低于微量白蛋白尿的DN患者。大量蛋白尿的DN患者VASH-1水平高于微量白蛋白尿的DN患者（P<0.05）。25(OH)D3与CysC呈负相关,BUN,Scr,24h尿蛋白，CRP,TGF-β1,TNF-α,IL-6在DN患者中的表达(P<0.05)。VASH-1与Scr呈正相关,24h尿蛋白,CRP,TGF-β1、TNF-α和IL-6在DN患者中的表达(P<0.05)。
■DN患者血清25(OH)D3水平明显下降,VASH-1的水平提高了，与肾功能损伤程度及炎症反应有关。
