Abstract：
The study aimed to evaluate the relation between microcirculation of the genian region using laser Doppler flowmetry and oral mucositis (OM) and pain in individuals undergoing antineoplastic therapy. A case-control clinical study was conducted with the participants divided into three groups: chemotherapy (CTG), radiation therapy and chemotherapy group (RCTG), and control group (CG). Pain was assessed by visual analog scale; OM was classified by oral mucositis assessment and WHO scales. The blood flow was assessed by laser Doppler flowmetry. Kruskal-Wallis statistical test, Friedman test, and Spearman test were used for statistical analysis of this study. CTG (7 individuals/25.93%) showed the worst manifestations of OM between 2nd and 4th evaluations (OM-WHO: T2, p = 0.006; T3, p = 0.006; T4, p = 0.003; OM-OMAS: T2, p = 0.004; T3, p = 0.000; T4, p = 0.011), and increased blood flow over time, with the exception of the 3rd evaluation (p = 0.138). The RCTG (9 individuals/33.33%) showed the worst manifestations of oral mucositis on the 4th week (OM-WHO and OM-OMAS: p = 0.000) with a decrease in blood flow (p = 0.068). The decreased blood flow is associated with greater severity of oral mucositis and greater pain intensity.
摘要：
该研究旨在评估使用激光多普勒血流仪的Genian区域微循环与接受抗肿瘤治疗的个体的口腔粘膜炎（OM）和疼痛之间的关系。进行了一项病例对照临床研究，参与者分为三组：化疗（CTG），放疗和化疗组（RCTG），对照组（CG）。疼痛通过视觉模拟量表进行评估；OM通过口腔粘膜炎评估和WHO量表进行分类。通过激光多普勒血流仪评估血流。Kruskal-Wallis统计检验,弗里德曼测试,采用Spearman检验进行统计学分析。CTG（7个人/25.93％）在第2次和第4次评估中表现出最差的OM表现（OM-WHO：T2，p=0.006；T3，p=0.006；T4，p=0.003；OM-OMAS：T2，p=0.004；T3，p=0.000；T4，p=0.011），随着时间的推移血流量增加，除了第三次评估(p=0.138)。RCTG（9人/33.33％）在第4周表现出口腔粘膜炎的最严重表现（OM-WHO和OM-OMAS：p=0.000），血流量减少（p=0.068）。血流量减少与口腔粘膜炎的严重程度和疼痛强度有关。
