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Abstract：
Primary Sjögren syndrome (pSS) is a systemic autoimmune inflammatory disease. Up to now, the role of regulatory T cells (Tregs) and their subgroups in pSS is still in controversial. In this study we tried to elucidate the roles of Tregs and its subgroups in pSS. Total 43 pSS patients and 23 health persons as control were enrolled in this study. We grouped the pSS patients according to the anti-SSa/SSb and the EULAR Sjögren\'s syndrome disease activity index (ESSDAI). Among the 43 pSS patients, 14 patients were followed after treatment. The percentage of rTregs (resting Treg cells) among Tregs was increased in the pSS group, and decreased after treatment. In the high disease activity subpopulation (ESSDAI ≥ 5), the percentage of rTregs among Tregs decreased after treatment. On the contrary, the percentage of aTregs (activated Treg cells) increased after treatment. It was in an inverse correlation between the percentage of aTreg and rTreg in pSS patients. The Tregs are co-cultured with responder T cells. Tregs from pSS patients showed poorer proliferation inhibitory function. Our results show that the percentages of Tregs and their subgroups altered in pSS patients. The percentage of aTreg and the percentage of rTreg have an inverse correlation in pSS patients. Compared to the control group, the percentage of rTregs among Tregs was increased in the pSS patients and decreased after the treatment. Our study also showed that The Tregs from pSS patients may have poorer inhibitory functions.
摘要：
原发性干燥综合征(pSS)是一种全身性自身免疫性炎性疾病。到目前为止,调节性T细胞（Tregs）及其亚群在pSS中的作用仍存在争议。在这项研究中，我们试图阐明Tregs及其亚群在pSS中的作用。本研究共纳入43例pSS患者和23例健康者作为对照。我们根据抗SSa/SSb和EULAR干燥综合征疾病活动指数（ESSDAI）对pSS患者进行分组。在43名pSS患者中，治疗后随访14例。在pSS组中，Treg细胞（静息Treg细胞）在Treg中的百分比增加，治疗后下降。在高疾病活动性亚群（ESSDAI≥5）中，治疗后，Tregs中rTregs的百分比下降。相反,治疗后aTregs（活化的Treg细胞）的百分比增加。pSS患者中aTreg和rTreg的百分比呈负相关。将Treg与应答T细胞共培养。来自pSS患者的Tregs显示较差的增殖抑制功能。我们的结果表明，在pSS患者中，Tregs及其亚组的百分比发生了变化。在pSS患者中，aTreg的百分比和rTreg的百分比呈负相关。与对照组相比,在pSS患者中,rTregs在Tregs中的百分比升高,治疗后下降.我们的研究还表明，来自pSS患者的Tregs可能具有较差的抑制功能。
