EMbase, Web of Science, PubMed, and The Cochrane Library were searched up to September 18th, 2022. Two reviewers independently extracted data and evaluated risk of bias of included studies by ROBINS-I tool. A meta-regression analysis was conducted using a mixed-effects model to explore possible sources of heterogeneity. A random-effects model was used for pooled analysis in case of significant heterogeneity (I2>50%). Otherwise, the fixed-effects model was performed.
A total of 157 studies (37,915 enrolled patients) were included in the meta-analysis. The pooled death proportions of KPB were 17% (95% CI=0.14-0.20) at 7-day, 24% (95% CI=0.21-0.28) at 14-day, 29% (95% CI=0.26-0.31) at 30-day, 34% (95% CI=0.26-0.42) at 90-day, and 29% (95% CI=0.26-0.33) in hospital, respectively. Heterogeneity was found from the intensive care unit (ICU), hospital-acquired (HA), CRKP, and ESBL-KP in the meta-regression analysis. More than 50% of ICU, HA, CRKP, and ESBL-KP were associated with a significant higher 30-day mortality rates. The pooled mortality odds ratios (ORs) of CRKP vs. non-CRKP were 3.22 (95% CI 1.18-8.76) at 7-day, 5.66 (95% CI 4.31-7.42) at 14-day, 3.87 (95% CI 3.01-3.49) at 28- or 30-day, and 4.05 (95% CI 3.38-4.85) in hospital, respectively.
This meta-analysis indicated that patients with KPB in ICU, HA-KPB, CRKP, and ESBL-KP bacteremia were associated with a higher mortality rate. The high mortality rate caused by CRKP bacteremia has increased over time, challenging the public health.
■EMBase,WebofScience,PubMed,直到9月18日,科克伦图书馆都被搜查了,2022年。两名评审员独立提取数据,并通过ROBINS-I工具评估纳入研究的偏倚风险。使用混合效应模型进行荟萃回归分析,以探索异质性的可能来源。在显著异质性(I2>50%)的情况下,使用随机效应模型进行汇总分析。否则,采用固定效应模型.
■共有157项研究(37,915名入选患者)纳入荟萃分析。在7天,KPB的合并死亡比例为17%(95%CI=0.14-0.20),24%(95%CI=0.21-0.28)在14天,29%(95%CI=0.26-0.31)在30天,在90天,34%(95%CI=0.26-0.42),29%(95%CI=0.26-0.33)在医院,分别。从重症监护病房(ICU)发现异质性,医院获得性(HA),CRKP,和ESBL-KP在荟萃回归分析中的应用。超过50%的ICU,HA,CRKP,和ESBL-KP与显著较高的30天死亡率相关.CRKP与CRKP的合并死亡率优势比(ORs)7天的非CRKP为3.22(95%CI1.18-8.76),14天时5.66(95%CI4.31-7.42),在28天或30天时为3.87(95%CI3.01-3.49),和4.05(95%CI3.38-4.85)在医院,分别。
■这项荟萃分析表明,ICU中的KPB患者,HA-KPB,CRKP,和ESBL-KP菌血症与较高的死亡率相关。CRKP菌血症引起的高死亡率随着时间的推移而增加,挑战公众健康。