PDF(Pubmed)
Abstract：
UNASSIGNED: To assess the effect of combination therapy with 3% diquafosol tetrasodium (DQS) and sodium hyaluronate (HA) for dry eye after femtosecond laser-assisted in situ keratomileusis (FS-LASIK).
UNASSIGNED: Prospective nonrandomized comparative trial.
UNASSIGNED: The prospective study included 80 eyes of 40 patients who underwent FS-LASIK with or without preoperative dry eye. Patients were divided into a combination group and a HA group according to their willingness and the doctor\'s advice. The combination group was treated with DQS six times a day and HA four times a day, and the HA group was treated with HA four times a day after FS-LASIK. Ocular surface disease index (OSDI), ocular symptom score, vision-related score, environmental score, tear meniscus height (TMH), first non-invasive tear breakup time (NIBUT-First), average non-invasive tear breakup time (NIBUT-Ave), tear breakup time (TBUT), Schirmer I test (SIT), corneal fluorescein staining score (CFS), bulbar redness score, limbal redness score, lipid layer grade (LLG), meiboscore, lid margin abnormality, corneal sensitivity, and corneal nerve parameters were examined before surgery and at 1 week and 1 month after surgery. Surface regularity index (SRI) was also examined before surgery and at 1 month postoperatively.
UNASSIGNED: OSDI score (p = 0.024) and vision-related score (p = 0.026) were significantly lower in the combination group than in the HA group at 1 month after FS-LASIK, especially in patients with preoperative dry eye symptoms. The increasements of CFS (p = 0.018), bulbar redness score (p = 0.021), and limbal redness score (p = 0.009) were significantly lower in the combination group than in the HA group at 1 week after FS-LASIK. But other ocular surface parameters showed no difference between both groups at 1 week and 1 month after FS-LASIK. LLG was significantly higher in the combination group than in the HA group at 1 week (p = 0.004) and 1 month (p < 0.001) after surgery, especially in patients with high meiboscore. Additional DQS significantly improved corneal sensitivity in patients without preoperative dry eye symptoms at 1 month after FS-LASIK (p = 0.041).
UNASSIGNED: The combination therapy with DQS and HA significantly relieved subjective symptoms, improved ocular surface status, and had the potential to promote corneal nerve growth in patients after FS-LASIK.
UNASSIGNED: Prospective nonrandomized comparative trial.
UNASSIGNED: The prospective study included 80 eyes of 40 patients who underwent FS-LASIK with or without preoperative dry eye. Patients were divided into a combination group and a HA group according to their willingness and the doctor\'s advice. The combination group was treated with DQS six times a day and HA four times a day, and the HA group was treated with HA four times a day after FS-LASIK. Ocular surface disease index (OSDI), ocular symptom score, vision-related score, environmental score, tear meniscus height (TMH), first non-invasive tear breakup time (NIBUT-First), average non-invasive tear breakup time (NIBUT-Ave), tear breakup time (TBUT), Schirmer I test (SIT), corneal fluorescein staining score (CFS), bulbar redness score, limbal redness score, lipid layer grade (LLG), meiboscore, lid margin abnormality, corneal sensitivity, and corneal nerve parameters were examined before surgery and at 1 week and 1 month after surgery. Surface regularity index (SRI) was also examined before surgery and at 1 month postoperatively.
UNASSIGNED: OSDI score (p = 0.024) and vision-related score (p = 0.026) were significantly lower in the combination group than in the HA group at 1 month after FS-LASIK, especially in patients with preoperative dry eye symptoms. The increasements of CFS (p = 0.018), bulbar redness score (p = 0.021), and limbal redness score (p = 0.009) were significantly lower in the combination group than in the HA group at 1 week after FS-LASIK. But other ocular surface parameters showed no difference between both groups at 1 week and 1 month after FS-LASIK. LLG was significantly higher in the combination group than in the HA group at 1 week (p = 0.004) and 1 month (p < 0.001) after surgery, especially in patients with high meiboscore. Additional DQS significantly improved corneal sensitivity in patients without preoperative dry eye symptoms at 1 month after FS-LASIK (p = 0.041).
UNASSIGNED: The combination therapy with DQS and HA significantly relieved subjective symptoms, improved ocular surface status, and had the potential to promote corneal nerve growth in patients after FS-LASIK.
摘要：
■评估3％diquafosol四钠（DQS）和透明质酸钠（HA）联合治疗飞秒激光辅助原位角膜磨镶术（FS-LASIK）后干眼的效果。
■前瞻性非随机比较试验。
■这项前瞻性研究纳入了40例接受FS-LASIK手术的患者的80只眼，其中有或没有术前干眼。根据患者的意愿和医生的建议将患者分为联合组和HA组。联合组用DQS每天6次，HA每天4次，HA组在FS-LASIK术后每天4次接受HA治疗。眼表疾病指数（OSDI），眼部症状评分,视觉相关得分，环境评分,撕裂弯月面高度（TMH），第一次非侵入性泪液破裂时间（NIBUT-First），平均非侵入性泪液破裂时间（NIBUT-Ave），撕裂破裂时间（TBUT），SchirmerI测试（SIT），角膜荧光素染色评分（CFS），球根发红评分，角膜缘红肿评分,脂质层等级（LLG），meibocore,眼睑边缘异常,角膜敏感度,术前、术后1周、1个月检查角膜神经参数。手术前和术后1个月也检查了表面规整指数（SRI）。
■在FS-LASIK后1个月，联合组的OSDI评分（p=0.024）和视力相关评分（p=0.026）明显低于HA组，尤其是患者术前有干眼症状。CFS的增加(p=0.018)，球发红评分（p=0.021），FS-LASIK术后1周，联合组的角膜缘红肿评分（p=0.009）显着低于HA组。但其他眼表参数在FS-LASIK术后1周和1个月两组间无差异。术后1周(p=0.004)和1个月(p<0.001)联合组LLG显著高于HA组,尤其是高meiboboscore患者。在FS-LASIK术后1个月，额外的DQS可显着改善无术前干眼症状的患者的角膜敏感性（p=0.041）。
■DQS和HA联合治疗可显著缓解主观症状，改善眼表状态，并有可能促进FS-LASIK术后患者的角膜神经生长。
■前瞻性非随机比较试验。
■这项前瞻性研究纳入了40例接受FS-LASIK手术的患者的80只眼，其中有或没有术前干眼。根据患者的意愿和医生的建议将患者分为联合组和HA组。联合组用DQS每天6次，HA每天4次，HA组在FS-LASIK术后每天4次接受HA治疗。眼表疾病指数（OSDI），眼部症状评分,视觉相关得分，环境评分,撕裂弯月面高度（TMH），第一次非侵入性泪液破裂时间（NIBUT-First），平均非侵入性泪液破裂时间（NIBUT-Ave），撕裂破裂时间（TBUT），SchirmerI测试（SIT），角膜荧光素染色评分（CFS），球根发红评分，角膜缘红肿评分,脂质层等级（LLG），meibocore,眼睑边缘异常,角膜敏感度,术前、术后1周、1个月检查角膜神经参数。手术前和术后1个月也检查了表面规整指数（SRI）。
■在FS-LASIK后1个月，联合组的OSDI评分（p=0.024）和视力相关评分（p=0.026）明显低于HA组，尤其是患者术前有干眼症状。CFS的增加(p=0.018)，球发红评分（p=0.021），FS-LASIK术后1周，联合组的角膜缘红肿评分（p=0.009）显着低于HA组。但其他眼表参数在FS-LASIK术后1周和1个月两组间无差异。术后1周(p=0.004)和1个月(p<0.001)联合组LLG显著高于HA组,尤其是高meiboboscore患者。在FS-LASIK术后1个月，额外的DQS可显着改善无术前干眼症状的患者的角膜敏感性（p=0.041）。
■DQS和HA联合治疗可显著缓解主观症状，改善眼表状态，并有可能促进FS-LASIK术后患者的角膜神经生长。
