PDF(Pubmed)
Abstract：
UNASSIGNED: Financial hardship has been described as a patient\'s economic experiencefollowing cancer-related treatment. Standardized patient-reported outcome measures(PROM) to assess this distress has not been well-studied, especially among older cancer survivors.
UNASSIGNED: The aim of this study was to develop and validate PROM for assessing the financial hardship of older cancer survivors in China.
UNASSIGNED: Items were generated using qualitative interviews and literature review. Items were screened based on Delphi expert consultation and patients\' opinions. Item response theory (IRT) and classical test theory (CTT) were used to help reduce items. Retained items formed a pilot instrument that was subjected to psychometric testing. A cut-off score for the new instrument for predicting poor quality of life was identified by receiver operating characteristic (ROC) analysis.
UNASSIGNED: Qualitative interviews and literature review generated 135 items, which were reduced to 60 items because of redundancy. Following Delphi expert consultation and patients\' evaluation, 24 items with high importance were extracted. Sixteen items were selected due to satisfactory statistical analysis based on CTT and IRT. Ten items were retained and comprised 2 domains after loadings in exploratory factor analysis (EFA). Internal consistency was satisfactory (α = 0.838). Test-retest reliability was good (intraclass correlation, 0.909). The ROC analysis suggested that the cut-off of 18.5 yielded an acceptable sensitivity and specificity.
UNASSIGNED: The PROM for Hardship and Recovery with Distress Survey (HARDS) consists of 10 items that specifically reflect the experiences of financial hardship among older Chinese cancer survivors, and it also showed good reliability and validity in clinical settings.
UNASSIGNED: The aim of this study was to develop and validate PROM for assessing the financial hardship of older cancer survivors in China.
UNASSIGNED: Items were generated using qualitative interviews and literature review. Items were screened based on Delphi expert consultation and patients\' opinions. Item response theory (IRT) and classical test theory (CTT) were used to help reduce items. Retained items formed a pilot instrument that was subjected to psychometric testing. A cut-off score for the new instrument for predicting poor quality of life was identified by receiver operating characteristic (ROC) analysis.
UNASSIGNED: Qualitative interviews and literature review generated 135 items, which were reduced to 60 items because of redundancy. Following Delphi expert consultation and patients\' evaluation, 24 items with high importance were extracted. Sixteen items were selected due to satisfactory statistical analysis based on CTT and IRT. Ten items were retained and comprised 2 domains after loadings in exploratory factor analysis (EFA). Internal consistency was satisfactory (α = 0.838). Test-retest reliability was good (intraclass correlation, 0.909). The ROC analysis suggested that the cut-off of 18.5 yielded an acceptable sensitivity and specificity.
UNASSIGNED: The PROM for Hardship and Recovery with Distress Survey (HARDS) consists of 10 items that specifically reflect the experiences of financial hardship among older Chinese cancer survivors, and it also showed good reliability and validity in clinical settings.
摘要：
■经济困难被描述为患者在癌症相关治疗后的经济经历。评估这种痛苦的标准化患者报告结局指标（PROM）尚未得到很好的研究，尤其是老年癌症幸存者。
■本研究的目的是开发和验证PROM，以评估中国老年癌症幸存者的经济困难。
■使用定性访谈和文献综述生成项目。根据Delphi专家咨询和患者意见筛选项目。使用项目反应理论（IRT）和经典测试理论（CTT）来帮助减少项目。保留的物品形成了经过心理测试的先导仪器。通过受试者工作特征（ROC）分析确定了用于预测不良生活质量的新仪器的截止分数。
■定性访谈和文献综述产生了135个项目，由于冗余，它们减少到60个项目。在德尔福专家咨询和患者评估之后，提取了24个具有高重要性的项目。由于基于CTT和IRT的统计分析令人满意，因此选择了16个项目。在探索性因子分析（EFA）中加载后，保留了10个项目，包含2个域。内部一致性令人满意(α=0.838)。重测可靠性良好(组内相关性，0.909)。ROC分析表明，18.5的截止值产生了可接受的灵敏度和特异性。
■困难与痛苦康复调查（HARDS）包括10个项目，这些项目特别反映了中国老年癌症幸存者的经济困难经历，在临床环境中也显示出良好的信度和效度。
■本研究的目的是开发和验证PROM，以评估中国老年癌症幸存者的经济困难。
■使用定性访谈和文献综述生成项目。根据Delphi专家咨询和患者意见筛选项目。使用项目反应理论（IRT）和经典测试理论（CTT）来帮助减少项目。保留的物品形成了经过心理测试的先导仪器。通过受试者工作特征（ROC）分析确定了用于预测不良生活质量的新仪器的截止分数。
■定性访谈和文献综述产生了135个项目，由于冗余，它们减少到60个项目。在德尔福专家咨询和患者评估之后，提取了24个具有高重要性的项目。由于基于CTT和IRT的统计分析令人满意，因此选择了16个项目。在探索性因子分析（EFA）中加载后，保留了10个项目，包含2个域。内部一致性令人满意(α=0.838)。重测可靠性良好(组内相关性，0.909)。ROC分析表明，18.5的截止值产生了可接受的灵敏度和特异性。
■困难与痛苦康复调查（HARDS）包括10个项目，这些项目特别反映了中国老年癌症幸存者的经济困难经历，在临床环境中也显示出良好的信度和效度。
