PDF(Pubmed)
Abstract：
Pharmacy personnel that manipulate cytotoxic drugs are under continuous exposure risk. Therefore, training and strict adherence to recommended practices should always be promoted. The main objective of this study was to develop and apply a safe, effective and low-cost method for the training and assessment of the safe handling of cytotoxic drugs, using commercially available tonic water. To evaluate the potential of tonic water as a replacement marker for quinine hydrochloride, deliberate spills of 1 mL of four different tonic waters (one coloured and three non-coloured) were analysed under ultraviolet light (300-400 nm). The pigmented sample did not produce fluorescence under ultraviolet (UV) light. The three commercially available tonic waters that exhibited fluorescence were further analysed by UV/Vis spectrophotometry (300-500 nm). Afterwards, a protocol of simulated manipulation of cytotoxic drugs was developed and applied to 12 pharmacy technicians, that prepared 24 intravenous bags according to recommended routine procedures using tonic water. Participants responded to a brief questionnaire to evaluate the adequacy and applicability of the activity. Seven of the participants had spillages during manipulation, the majority of which recorded during manipulation with needles. All participants scored the tonic water manipulation simulation with 4 or 5 points for simplicity, efficiency and feasibility. The obtained results suggest that tonic water can be used to simulate the manipulation of cytotoxic drugs in training and assessment programs. By using this replacement marker for quinine hydrochloride, it is possible to perform a more cost-effective, yet equally effective, assessment.
摘要：
操作细胞毒性药物的药学人员处于持续暴露风险中。因此,应始终促进培训和严格遵守建议的做法。这项研究的主要目的是开发和应用一种安全的，有效和低成本的方法，用于培训和评估细胞毒性药物的安全处理，使用市售的补品水。为了评估补品水作为盐酸奎宁的替代标记的潜力，在紫外线(300-400纳米)下分析了1毫升四种不同滋补水(一种有色和三种无色)的故意溢出。着色样品在紫外(UV)光下不产生荧光。通过UV/Vis分光光度法(300-500nm)进一步分析显示荧光的三种市售滋补水。之后,开发了模拟细胞毒性药物操作的方案，并将其应用于12名药学技术人员，根据推荐的常规程序使用补品水制备了24个静脉注射袋。与会者回答了一份简短的问卷，以评估这项活动的充分性和适用性。七个参与者在操纵过程中溢出，其中大部分是在用针头操作期间记录的。为简单起见，所有参与者对滋补水操纵模拟进行了4或5分的评分，效率和可行性。获得的结果表明，补品水可用于模拟训练和评估计划中细胞毒性药物的操作。通过使用这种盐酸奎宁的替代标记，可以执行更具成本效益的，但同样有效，评估。
