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Abstract：
BACKGROUND: Alpha-fetoprotein-producing gastric cancer (AFPGC) is a rare type of aggressive gastric cancer (GC) with a dismal prognosis. We present a patient with AFPGC who achieved long-term survival through a multidisciplinary approach.
METHODS: A 67-year-old man with advanced GC was referred to our hospital for systemic chemotherapy. He was diagnosed with cStage IVB AFPGC. During 2nd-line treatment, we could not control bleeding from the GC itself. After complete resection, during chemotherapy, portal venous tumor thrombi (PVTTs) and liver metastases were identified. With nivolumab followed by irinotecan, the PVTTs and liver metastases disappeared. Without immunotherapy and chemotherapy for 23 months, the patient has survived for 48 months so far with no recurrence of GC.
CONCLUSIONS: Long-term survival with AFPGC can be accomplished by using several different approaches, such as surgery, immunotherapy, and chemotherapy.
METHODS: A 67-year-old man with advanced GC was referred to our hospital for systemic chemotherapy. He was diagnosed with cStage IVB AFPGC. During 2nd-line treatment, we could not control bleeding from the GC itself. After complete resection, during chemotherapy, portal venous tumor thrombi (PVTTs) and liver metastases were identified. With nivolumab followed by irinotecan, the PVTTs and liver metastases disappeared. Without immunotherapy and chemotherapy for 23 months, the patient has survived for 48 months so far with no recurrence of GC.
CONCLUSIONS: Long-term survival with AFPGC can be accomplished by using several different approaches, such as surgery, immunotherapy, and chemotherapy.
摘要：
背景：产生甲胎蛋白的胃癌（AFPGC）是一种罕见的侵袭性胃癌（GC），预后不佳。我们介绍了一名AFPGC患者，他通过多学科方法获得了长期生存。
方法：一名67岁的晚期GC患者被转诊到我院进行全身化疗。他被诊断为cStageIVBAFPGC。在二线治疗期间，我们无法控制GC本身的出血。完全切除后,化疗期间,发现门静脉癌栓（PVTT）和肝转移。纳武单抗和伊立替康,PVTT和肝转移消失。23个月没有免疫治疗和化疗，患者至今已存活48个月,无GC复发.
结论：AFPGC的长期生存可以通过使用几种不同的方法来实现，比如手术，免疫疗法，和化疗。
方法：一名67岁的晚期GC患者被转诊到我院进行全身化疗。他被诊断为cStageIVBAFPGC。在二线治疗期间，我们无法控制GC本身的出血。完全切除后,化疗期间,发现门静脉癌栓（PVTT）和肝转移。纳武单抗和伊立替康,PVTT和肝转移消失。23个月没有免疫治疗和化疗，患者至今已存活48个月,无GC复发.
结论：AFPGC的长期生存可以通过使用几种不同的方法来实现，比如手术，免疫疗法，和化疗。
