Abstract：
Biliary cysts (BC) is a rare indication for orthotopic liver transplantation (OLT).
We queried the UNOS dataset to identify patients who underwent OLT for Caroli\'s disease (CD) and choledochal cysts (CC). All patients with BC (CD + CC) were compared to a cohort of patients transplanted for other indications. Patients with CC were also compared to those with CD. Cox proportional hazard model was performed to assess predictors of graft and patient survival.
261 patients underwent OLT for BC. Patients with BC had better pre-operative liver function compared to those transplanted for other indications. 5-year graft and patient survival were 72% and 81%, respectively, similar to those transplanted for other indications after matching. Patients with CC were younger and had increased preoperative cholestasis compared to those with CD. Donor age, race, and gender were predictors of poor graft and patient survival in patients transplanted for CC.
Patients with BC have similar outcomes to those transplanted for other indications and more frequently require MELD score exception. In patients transplanted for choledochal cysts, female gender, donor age, and African-American race were independent predictors of poor survival. Pediatric patients transplanted for Caroli\'s disease had better survival compared to adults.
We queried the UNOS dataset to identify patients who underwent OLT for Caroli\'s disease (CD) and choledochal cysts (CC). All patients with BC (CD + CC) were compared to a cohort of patients transplanted for other indications. Patients with CC were also compared to those with CD. Cox proportional hazard model was performed to assess predictors of graft and patient survival.
261 patients underwent OLT for BC. Patients with BC had better pre-operative liver function compared to those transplanted for other indications. 5-year graft and patient survival were 72% and 81%, respectively, similar to those transplanted for other indications after matching. Patients with CC were younger and had increased preoperative cholestasis compared to those with CD. Donor age, race, and gender were predictors of poor graft and patient survival in patients transplanted for CC.
Patients with BC have similar outcomes to those transplanted for other indications and more frequently require MELD score exception. In patients transplanted for choledochal cysts, female gender, donor age, and African-American race were independent predictors of poor survival. Pediatric patients transplanted for Caroli\'s disease had better survival compared to adults.
摘要：
背景：胆道囊肿（BC）是原位肝移植（OLT）的罕见指征。
方法：我们查询了UNOS数据集，以确定因Caroli病（CD）和胆总管囊肿（CC）而接受OLT的患者。将所有BC（CDCC）患者与其他适应症移植的患者队列进行比较。还将患有CC的患者与患有CD的患者进行比较。进行Cox比例风险模型以评估移植物和患者存活的预测因子。
结果：261例患者因BC行OLT。与其他适应症移植的患者相比，BC患者的术前肝功能更好。5年移植物和患者生存率分别为72％和81％，分别,与匹配后移植的其他适应症相似。与CD患者相比，CC患者更年轻，术前胆汁淤积增加。捐赠者年龄,种族,性别和性别是CC移植患者移植物和患者存活率差的预测因素。
结论：BC患者与其他适应症的移植结果相似，更常见的是需要MELD评分例外。在胆总管囊肿移植的患者中，女性性别,供体年龄,和非裔美国人种族是生存不佳的独立预测因素。与成人相比，因Caroli病移植的小儿患者的生存率更好。
方法：我们查询了UNOS数据集，以确定因Caroli病（CD）和胆总管囊肿（CC）而接受OLT的患者。将所有BC（CDCC）患者与其他适应症移植的患者队列进行比较。还将患有CC的患者与患有CD的患者进行比较。进行Cox比例风险模型以评估移植物和患者存活的预测因子。
结果：261例患者因BC行OLT。与其他适应症移植的患者相比，BC患者的术前肝功能更好。5年移植物和患者生存率分别为72％和81％，分别,与匹配后移植的其他适应症相似。与CD患者相比，CC患者更年轻，术前胆汁淤积增加。捐赠者年龄,种族,性别和性别是CC移植患者移植物和患者存活率差的预测因素。
结论：BC患者与其他适应症的移植结果相似，更常见的是需要MELD评分例外。在胆总管囊肿移植的患者中，女性性别,供体年龄,和非裔美国人种族是生存不佳的独立预测因素。与成人相比，因Caroli病移植的小儿患者的生存率更好。
