Abstract：
Growing evidence suggests there is a bidirectional relationship between depression and obesity, which are associated with structural and functional brain abnormalities. However, the underlying neurobiological mechanisms subserving the foregoing associations have yet to be characterized. It is necessary to summarize the neuroplastic brain changes in relation to depression and obesity. We systematically searched articles from 1990 to November 2022 on databases including MEDLINE/PubMed, Web of Science, PsycINFO. Only neuroimaging studies within the scope of potential differences in brain function and structure in individuals with depression and obesity/ BMI changes were included. Twenty-four eligible studies were included in the review herein, consisting of 17 studies reporting changes in brain structure, 4 studies reporting abnormal brain function, and 3 studies reporting both changes in brain structure and function. Results indicated an interaction between depression and obesity on brain functions, and their influence on brain structure is both extensive and specific. Overall, reduced whole brain, intracranial, and gray matter volume (e.g. frontal, temporal gyri, thalamic, and hippocampal) and impaired white matter integrity was observed in persons with depression and obesity comorbidity. Additional evidence on resting state fMRI reveals select brain regions associated with cognitive control, emotion regulation, and reward functions. Due to the diversity of tasks in task fMRI, the distinct neural activation patterns are revealed separately. The bidirectional relationship between depression and obesity reflects different characteristics in brain structure and function. Longitudinal designs should be reinforced in follow-up studies.
摘要：
越来越多的证据表明，抑郁和肥胖之间存在双向关系，与大脑结构和功能异常有关。然而,属于上述关联的潜在神经生物学机制尚未被表征。有必要总结与抑郁和肥胖有关的神经可塑性大脑变化。我们系统地搜索了1990年至2022年11月在数据库上的文章，包括MEDLINE/PubMed，WebofScience,PsycINFO。仅包括患有抑郁症和肥胖/BMI变化的个体的脑功能和结构的潜在差异范围内的神经影像学研究。24项符合条件的研究纳入本文的综述，由17项报告大脑结构变化的研究组成，4项研究报告脑功能异常，3项研究报告了大脑结构和功能的变化。结果表明抑郁症和肥胖对大脑功能的相互作用，它们对大脑结构的影响是广泛而具体的。总的来说,减少整个大脑，颅内,和灰质体积(例如额叶，颞叶回,丘脑,和海马），并且在患有抑郁症和肥胖症合并症的人中观察到白质完整性受损。静息状态功能磁共振成像的其他证据揭示了与认知控制相关的大脑区域，情绪调节,和奖励功能。由于fMRI任务的多样性,不同的神经激活模式分别显示。抑郁症与肥胖之间的双向关系反映了大脑结构和功能的不同特征。在后续研究中应加强纵向设计。
