Records of NCVs for headaches, concentrations of ambient NO2, and meteorological variables were collected in Wuhan, China, from January 1st, 2017, to November 30th, 2019. A time-series study was conducted to investigate the short-term effects of NO2 exposure on daily NCVs for headaches. Stratified analyses were also computed according to season, age, and sex, and the exposure-response (E-R) curve was then plotted.
A total of 11,436 records of NCVs for headaches were enrolled in our study during the period. A 10-μg/m3 increase of ambient NO2 corresponded to a 3.64% elevation of daily NCVs for headaches (95%CI: 1.02%, 6.32%, P = 0.006). Moreover, females aged less than 50 years of age were more susceptible compared to males (4.10% vs. 2.97%, P = 0.007). The short-term effects of NO2 exposure on daily NCVs for headaches were stronger in cool seasons than in warm seasons (6.31% vs. 0.79%, P = 0.0009).
Our findings highlight that short-term exposure to ambient NO2 positively correlated with NCVs for headaches in Wuhan, China, and the adverse effects varied by season, age, and sex.
方法:头痛的NCV记录,收集了武汉的环境NO2浓度和气象变量,中国,从1月1日,2017年11月30日,2019.进行了时间序列研究,以调查NO2暴露对头痛的每日NCV的短期影响。还根据季节计算了分层分析,年龄,和性,然后绘制暴露-反应(E-R)曲线。
结果:本研究期间共纳入了11,436条头痛的NCV记录。环境NO2的10-μg/m3增加对应于头痛的每日NCV的3.64%升高(95CI:1.02%,6.32%,P=0.006)。此外,与男性相比,年龄小于50岁的女性更容易受到影响(4.10%vs.2.97%,P=0.007)。在凉爽季节,NO2暴露对头痛的每日NCV的短期影响比在温暖季节更强(6.31%vs.0.79%,P=0.0009)。
结论:我们的发现强调,在武汉,短期暴露于环境NO2与NCV的头痛呈正相关,中国,不利影响因季节而异,年龄,和性爱。