PDF(Pubmed)
Abstract：
BACKGROUND: Worldwide, a significant proportion of head and neck cancers is attributed to the Human papillomavirus (HPV). It is imperative that we acquire a solid understanding of the natural history of this virus in head and neck squamous cell carcinoma (HNSCC) development. Our objective was to investigate the role of sexual behaviour in the occurrence of HNSCC in the French West Indies. Additionally, we evaluated the association of high risk of HPV (Hr-HPV) with sexual behaviour in risk of cancer.
METHODS: We conducted a population-based case-control study (145 cases and 405 controls). We used logistic regression models to estimate adjusted odds-ratios (OR), and their 95% confidence intervals (CI).
RESULTS: Compared to persons who never practiced oral sex, those who practiced at least occasionally had a lower HNSCC risk. First sexual intercourse after the age of 18 year was associated with a 50% reduction of HNSCC risk, compared to those who began before 15 years. HNSCC risk was significantly reduced by 60% among persons who used condoms at least occasionally. The associations for ever condom use and oral sex were accentuated following the adjustment for high-risk HPV (Hr-HPV). Oral Hr-HPV was associated with several sexual behaviour variables among HNSCC cases. However, none of these variables were significantly associated with oral HPV infections in the population controls.
CONCLUSIONS: First intercourse after 18 years, short time interval since last intercourse and ever condom use were inversely associated with HNSCC independently of oral Hr-HPV infection. Sources of transmission other than sexual contact and the interaction between HPV and HIV could also play a role in HNSCC etiology.
METHODS: We conducted a population-based case-control study (145 cases and 405 controls). We used logistic regression models to estimate adjusted odds-ratios (OR), and their 95% confidence intervals (CI).
RESULTS: Compared to persons who never practiced oral sex, those who practiced at least occasionally had a lower HNSCC risk. First sexual intercourse after the age of 18 year was associated with a 50% reduction of HNSCC risk, compared to those who began before 15 years. HNSCC risk was significantly reduced by 60% among persons who used condoms at least occasionally. The associations for ever condom use and oral sex were accentuated following the adjustment for high-risk HPV (Hr-HPV). Oral Hr-HPV was associated with several sexual behaviour variables among HNSCC cases. However, none of these variables were significantly associated with oral HPV infections in the population controls.
CONCLUSIONS: First intercourse after 18 years, short time interval since last intercourse and ever condom use were inversely associated with HNSCC independently of oral Hr-HPV infection. Sources of transmission other than sexual contact and the interaction between HPV and HIV could also play a role in HNSCC etiology.
摘要：
背景：全球，相当比例的头颈部癌症归因于人乳头瘤病毒(HPV)。我们必须对这种病毒在头颈部鳞状细胞癌（HNSCC）发展中的自然史有深入的了解。我们的目的是调查性行为在法属西印度群岛HNSCC发生中的作用。此外,我们评估了高危型HPV(Hr-HPV)与性行为在癌症风险中的相关性.
方法：我们进行了一项基于人群的病例对照研究（145例病例和405例对照）。我们使用逻辑回归模型来估计调整后的优势比(OR)，和他们的95%置信区间(CI)。
结果：与从未进行过口交的人相比，那些至少偶尔练习的人HNSCC风险较低.18岁后的首次性交与HNSCC风险降低50％相关，与15年前开始的人相比。在至少偶尔使用避孕套的人群中，HNSCC风险显着降低了60％。调整高危型HPV（Hr-HPV）后，安全套使用和口交的关联得到了加强。口服Hr-HPV与HNSCC病例中的几种性行为变量相关。然而,在人群对照组中,这些变量均未与口腔HPV感染显著相关.
结论：18年后的第一次性交，自上一次性交以来的短时间间隔和使用避孕套与HNSCC呈负相关,而与口服Hr-HPV感染无关.除了性接触之外的传播源以及HPV和HIV之间的相互作用也可能在HNSCC病因中发挥作用。
方法：我们进行了一项基于人群的病例对照研究（145例病例和405例对照）。我们使用逻辑回归模型来估计调整后的优势比(OR)，和他们的95%置信区间(CI)。
结果：与从未进行过口交的人相比，那些至少偶尔练习的人HNSCC风险较低.18岁后的首次性交与HNSCC风险降低50％相关，与15年前开始的人相比。在至少偶尔使用避孕套的人群中，HNSCC风险显着降低了60％。调整高危型HPV（Hr-HPV）后，安全套使用和口交的关联得到了加强。口服Hr-HPV与HNSCC病例中的几种性行为变量相关。然而,在人群对照组中,这些变量均未与口腔HPV感染显著相关.
结论：18年后的第一次性交，自上一次性交以来的短时间间隔和使用避孕套与HNSCC呈负相关,而与口服Hr-HPV感染无关.除了性接触之外的传播源以及HPV和HIV之间的相互作用也可能在HNSCC病因中发挥作用。
