RESULTS: To eventually allow switching from batch to continuous production, conventional batch extraction and membrane-based microfluidic extraction were compared. In both approaches, Ga-68 was extracted using N-benzoyl-N-phenylhydroxylamine in chloroform as the organic extracting phase. Extraction efficiencies of up to 99.5% ± 0.6% were achieved within 10 min, using the batch approach. Back-extraction of Ga-68 into 2 M HCl was accomplished within 1 min with efficiencies of up to 94.5% ± 0.6%. Membrane-based microfluidic extraction achieved 99.2% ± 0.3% extraction efficiency and 95.8% ± 0.8% back-extraction efficiency into 6 M HCl. When executed on a solution irradiated with a 13 MeV cyclotron at TRIUMF, Canada, comparable efficiencies of 97.0% ± 0.4% were achieved. Zn contamination in the back-extracted Ga-68 solution was found to be below 3 ppm.
CONCLUSIONS: Microfluidic solvent extraction is a promising method in the production of Ga-68 achieving high efficiencies in a short amount of time, potentially allowing for direct target recycling.
结果:为了最终允许从批量生产切换到连续生产,比较了传统的间歇萃取和基于膜的微流控萃取。在这两种方法中,使用在氯仿中的N-苯甲酰基-N-苯基羟胺作为有机萃取相萃取Ga-68。在10分钟内达到高达99.5%±0.6%的提取效率,使用批处理方法。在1分钟内将Ga-68反萃取到2MHCl中,效率高达94.5%±0.6%。基于膜的微流体萃取在6MHCl中实现了99.2%±0.3%的萃取效率和95.8%±0.8%的反萃取效率。当在TRIUMF下用13MeV回旋加速器辐照的溶液上执行时,加拿大,达到了97.0%±0.4%的相当效率.发现反萃取的Ga-68溶液中的Zn污染低于3ppm。
结论:微流体溶剂萃取是生产Ga-68的一种有前途的方法,可在短时间内实现高效率,可能允许直接目标回收。