PDF(Pubmed)
Abstract：
UNASSIGNED: Patients with malignant brain tumors frequently exhibit hypercoagulation and are at a high risk of postoperative thrombosis-related complications. However, the risk factors for postoperative thrombosis-related complications remain unclear.
UNASSIGNED: In this retrospective, observational study, we consecutively enrolled elective patients undergoing resection of malignant brain tumors from 26 November 2018 to 30 September 2021. The primary objective of the study was to identify risk factors for a composite of three major adverse events including postoperative lower limb deep venous thrombosis, pulmonary embolism, and cerebral ischemia.
UNASSIGNED: A total of 456 patients were enrolled in this study, where 112 (24.6%) patients had postoperative thrombosis-related complications, 84 (18.4%) with lower limb deep venous thrombosis, 0 (0.0%) with pulmonary embolism, and 42 (9.2%) with cerebral ischemia. In a multivariate model, age more than 60 years (OR: 3.98, 95% CI: 2.30-6.88, P < 0.001), preoperative abnormal APTT (OR: 2.81, 95% CI: 1.06-7.42, P = 0.037), operation duration longer than 5 h (OR: 2.36, 95% CI: 1.34-4.16, P = 0.003), and admission to ICU (OR: 2.49, 95% CI: 1.21-5.12, P = 0.013) were independent risk factors of the postoperative deep vein thrombosis. Intraoperative plasma transfusion (OR: 6.85, 95% CI: 2.73-17.18, P < 0.001) was associated with significantly increased odds of deep vein thrombosis.
UNASSIGNED: Patients with craniocerebral malignant tumors have a high incidence of postoperative thrombosis-related complications. There is an increase in the odds of postoperative lower limb deep venous thrombosis in patients; over 60 years old, with preoperative abnormal APTT, undergoing surgeries longer than 5-h, admission to ICU, or receiving intraoperative plasma infusion. Fresh frozen plasma infusion should be used more cautiously, especially in patients with a high risk of thrombosis.
UNASSIGNED: In this retrospective, observational study, we consecutively enrolled elective patients undergoing resection of malignant brain tumors from 26 November 2018 to 30 September 2021. The primary objective of the study was to identify risk factors for a composite of three major adverse events including postoperative lower limb deep venous thrombosis, pulmonary embolism, and cerebral ischemia.
UNASSIGNED: A total of 456 patients were enrolled in this study, where 112 (24.6%) patients had postoperative thrombosis-related complications, 84 (18.4%) with lower limb deep venous thrombosis, 0 (0.0%) with pulmonary embolism, and 42 (9.2%) with cerebral ischemia. In a multivariate model, age more than 60 years (OR: 3.98, 95% CI: 2.30-6.88, P < 0.001), preoperative abnormal APTT (OR: 2.81, 95% CI: 1.06-7.42, P = 0.037), operation duration longer than 5 h (OR: 2.36, 95% CI: 1.34-4.16, P = 0.003), and admission to ICU (OR: 2.49, 95% CI: 1.21-5.12, P = 0.013) were independent risk factors of the postoperative deep vein thrombosis. Intraoperative plasma transfusion (OR: 6.85, 95% CI: 2.73-17.18, P < 0.001) was associated with significantly increased odds of deep vein thrombosis.
UNASSIGNED: Patients with craniocerebral malignant tumors have a high incidence of postoperative thrombosis-related complications. There is an increase in the odds of postoperative lower limb deep venous thrombosis in patients; over 60 years old, with preoperative abnormal APTT, undergoing surgeries longer than 5-h, admission to ICU, or receiving intraoperative plasma infusion. Fresh frozen plasma infusion should be used more cautiously, especially in patients with a high risk of thrombosis.
摘要：
■患有恶性脑肿瘤的患者经常表现出高凝，并且术后血栓形成相关并发症的风险很高。然而,术后血栓相关并发症的危险因素尚不清楚.
■在这次回顾中，观察性研究，我们从2018年11月26日至2021年9月30日连续纳入接受恶性脑肿瘤切除术的择期患者.该研究的主要目的是确定包括术后下肢深静脉血栓在内的三种主要不良事件的复合危险因素。肺栓塞,和脑缺血。
■本研究共纳入456名患者，其中112例（24.6%）患者有术后血栓相关并发症，84例（18.4%）下肢深静脉血栓形成，0（0.0％）合并肺栓塞，42例(9.2%)伴有脑缺血。在多变量模型中，年龄大于60岁（OR：3.98，95%CI：2.30-6.88，P<0.001），术前异常APTT(OR:2.81,95%CI:1.06-7.42,P=0.037),手术持续时间大于5小时(OR:2.36,95%CI:1.34-4.16,P=0.003),入ICU(OR:2.49,95%CI:1.21~5.12,P=0.013)是术后深静脉血栓形成的独立危险因素。术中血浆输注（OR：6.85，95％CI：2.73-17.18，P<0.001）与深静脉血栓形成的几率显着增加有关。
■颅脑恶性肿瘤患者术后血栓形成相关并发症的发生率很高。患者术后下肢深静脉血栓形成的几率增加；60岁以上，术前异常APTT，接受超过5小时的手术，入住ICU,或接受术中血浆输注。新鲜冰冻血浆输注应谨慎使用，尤其是血栓形成风险高的患者。
■在这次回顾中，观察性研究，我们从2018年11月26日至2021年9月30日连续纳入接受恶性脑肿瘤切除术的择期患者.该研究的主要目的是确定包括术后下肢深静脉血栓在内的三种主要不良事件的复合危险因素。肺栓塞,和脑缺血。
■本研究共纳入456名患者，其中112例（24.6%）患者有术后血栓相关并发症，84例（18.4%）下肢深静脉血栓形成，0（0.0％）合并肺栓塞，42例(9.2%)伴有脑缺血。在多变量模型中，年龄大于60岁（OR：3.98，95%CI：2.30-6.88，P<0.001），术前异常APTT(OR:2.81,95%CI:1.06-7.42,P=0.037),手术持续时间大于5小时(OR:2.36,95%CI:1.34-4.16,P=0.003),入ICU(OR:2.49,95%CI:1.21~5.12,P=0.013)是术后深静脉血栓形成的独立危险因素。术中血浆输注（OR：6.85，95％CI：2.73-17.18，P<0.001）与深静脉血栓形成的几率显着增加有关。
■颅脑恶性肿瘤患者术后血栓形成相关并发症的发生率很高。患者术后下肢深静脉血栓形成的几率增加；60岁以上，术前异常APTT，接受超过5小时的手术，入住ICU,或接受术中血浆输注。新鲜冰冻血浆输注应谨慎使用，尤其是血栓形成风险高的患者。
