PDF(Pubmed)
Abstract：
Neutrophil Extracellular Traps (NETs) are a key form of pro-inflammatory cell death of neutrophils characterized by the extrusion of extracellular webs of DNA containing bactericidal killing enzymes. NETosis is heavily implicated as a key driver of host damage in autoimmune diseases where injurious release of proinflammatory enzymes damage surrounding tissue and releases 70 known autoantigens. Recent evidence shows that both neutrophils and NETosis have a role to play in carcinogenesis, both indirectly through triggering DNA damage through inflammation, and directly contributing to a pro-tumorigenic tumor microenvironment. In this mini-review, we summarize the current knowledge of the various mechanisms of interaction and influence between neutrophils, with particular attention to NETosis, and cancer cells. We will also highlight the potential avenues thus far explored where we can intercept these processes, with the aim of identifying promising prospective targets in cancer treatment to be explored in further studies.
摘要：
中性粒细胞胞外陷阱(NETs)是中性粒细胞的促炎细胞死亡的关键形式,其特征在于含有杀菌杀伤酶的DNA的胞外网的挤出。NETosis被认为是自身免疫性疾病中宿主损伤的关键驱动因素，其中促炎酶的有害释放会损伤周围组织并释放70种已知的自身抗原。最近的证据表明，中性粒细胞和NETosis在癌变中起作用，两者都间接通过炎症引发DNA损伤，并直接导致肿瘤微环境。在这个小型审查中，我们总结了中性粒细胞之间相互作用和影响的各种机制的当前知识，特别关注NETosis，和癌细胞。我们还将强调迄今为止探索的潜在途径，我们可以拦截这些过程，目的是确定癌症治疗中有希望的前瞻性靶标，以供进一步研究探索。
