PDF(Pubmed)
Abstract：
Objective This study aimed to investigate the cytomorphological effects of heavyweight and lightweight mesh on the ilioinguinal nerve in an experimental animal model. Methods Sixteen New Zealand male rabbits were included in the study. The left inguinal regions of the first six animals were assigned as controls and the right inguinal regions were assigned as the sham group. The left inguinal regions of the remaining 10 animals were assigned as the lightweight mesh group and the right inguinal regions were assigned as the heavyweight mesh group. No intervention was performed in the control group. In the sham group, only ilioinguinal nerve exploration was performed. In mesh groups, ilioinguinal nerve exploration was performed and the mesh was implanted on the ilioinguinal nerve. After three months, ilioinguinal nerve specimens were excised from both sides for cytomorphological examination. Results Myelin sheath thickening, separation of the myelin layers, and myelin vacuolization were more pronounced in the heavyweight mesh group compared to the lightweight mesh group. The G-ratio was moderately increased in the heavyweight mesh group when compared to other groups. The ratio of fibers with ≤4 µm diameter was higher in the lightweight mesh group compared to other groups, and the ratio of fibers with ≥9 µm diameter was higher in the heavyweight mesh group than in the other groups (p<0.05). Conclusion Both of the meshes induce cytomorphological alterations on the adjacent nerve tissues caused by foreign body reaction and compression. Ilioinguinal nerve degeneration was more pronounced in the heavyweight mesh than in the lightweight mesh. Histological alterations on the ilioinguinal nerves caused by different meshes may be related to chronic pain after hernia surgery. We believe our study will serve as a guide for future studies on the topic.
摘要：
目的探讨重轻网片对实验动物模型髂腹股沟神经的细胞形态学影响。方法16只新西兰雄性兔纳入研究。前六只动物的左腹股沟区被指定为对照,右腹股沟区被指定为假手术组。其余10只动物的左侧腹股沟区域被分配为轻质网格组,右侧腹股沟区域被分配为重量级网格组。对照组不进行干预。在假小组中，仅进行髂腹股沟神经探查.在网格组中，进行髂腹股沟神经探查，并将网状物植入髂腹股沟神经。三个月后,从两侧切除髂腹股沟神经标本进行细胞形态学检查。结果髓鞘增厚,髓鞘层的分离，与轻量级网格组相比，重量级网格组的髓鞘空泡化更为明显。与其他组相比，重量级网格组的G比率适度增加。与其他组相比，轻质网格组中直径≤4µm的纤维比例更高，重量级网眼组直径≥9µm的纤维比例高于其他组（p<0.05）。结论两种网状物均可引起异物反应和压迫引起的邻近神经组织的细胞形态学改变。重量级网状物中的髂腹股沟神经变性比轻型网状物中的更为明显。不同网眼引起的髂腹股沟神经组织学改变可能与疝气手术后的慢性疼痛有关。我们相信我们的研究将作为未来研究的指南。
