关键词: AICVD ANS SSR acute ischemic cerebrovascular disease autonomic nervous system sympathetic skin response

来  源:   DOI:10.2147/IJGM.S405495   PDF(Pubmed)

Abstract:
UNASSIGNED: The study aims to identify the characteristics of SSR in patients with AICVD and their correlation with clinical presentations.
UNASSIGNED: SSR of the upper limbs, the National Institute of Health stroke scale (NIHSS), the Barthel index (BI), the Essen stroke risk score (ESRS), and imaging examinations, was evaluated in 30 healthy subjects and 66 patients with AICVD. All results were recorded and analyzed via Statistical Package for the Social Sciences (SPSS 22.0) software. t-test and Spearman rank correlation were used.
UNASSIGNED: Compared to the control group, SSR of upper limbs in patients with AICVD showed prolonged latency, reduced amplitude, and disappeared waveform (p=0.000, p=0.015, p=0.004), No statistically significant difference was observed between the affected side and the healthy side (p=0.068, p=0.661). In the case group, the higher the abnormal rate of SSR, the more severe the neurological impairment (NIHSS and ADL scores) and the worse the long-term prognosis. Specific results are as follows: Firstly, the total abnormality rate of SSR, prolonged SSR latency were positively related to the NIHSS, also the ESRS (r=0.347, p=0.004; r=0.437, p<0.001), (r=0.371, p=0.005; r=0.433, p=0.001), the reduced amplitude was positively related to the NIHSS (r=0.341, p=0.012) while the disappeared waveform was positively related to the ESRS (r=0.299, p=0.015); Secondly, the total abnormality rate of SSR, prolonged SSR latency and reduced amplitude were negatively related to the BI (r=-0.346, p=0.004) (r=-0.426, p=0.001) (r=-0.316, p=0.020).
UNASSIGNED: There may be inhibition of sympathetic reflex activity in patients with AICVD, SSR abnormality rate in patients with AICVD may be correlated with the degree of neurological impairment and long-term prognosis.
摘要:
该研究旨在确定AICVD患者的SSR特征及其与临床表现的相关性。
上肢的SSR,美国国立卫生研究院卒中量表(NIHSS),Barthel指数(BI),埃森中风风险评分(ESRS),和影像学检查,对30例健康受试者和66例AICVD患者进行了评估。通过社会科学统计软件包(SPSS22.0)软件记录和分析所有结果。采用t检验和Spearman秩相关。
与对照组相比,AICVD患者上肢SSR显示潜伏期延长,降低振幅,和消失波形(p=0.000,p=0.015,p=0.004),在患侧和健康侧之间没有观察到统计学上的显着差异(p=0.068,p=0.661)。在案例组中,SSR异常率越高,神经功能缺损(NIHSS和ADL评分)越严重,长期预后越差。具体结果如下:首先,SSR的总异常率,延长的SSR潜伏期与NIHSS呈正相关,ESRS(r=0.347,p=0.004;r=0.437,p<0.001),(r=0.371,p=0.005;r=0.433,p=0.001),波幅降低与NIHSS呈正相关(r=0.341,p=0.012),波幅消失与ESRS呈正相关(r=0.299,p=0.015);SSR的总异常率,延长的SSR潜伏期和降低的幅度与BI呈负相关(r=-0.346,p=0.004)(r=-0.426,p=0.001)(r=-0.316,p=0.020)。
AICVD患者可能存在交感神经反射活动抑制,AICVD患者SSR异常率可能与神经功能缺损程度及远期预后相关。
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