Abstract：
In this study we undertook a comprehensive analysis of a Pet Tumour Registry of the Canary Archipelago (PTR-CA) in Spain to investigate the epidemiology of canine cutaneous round cell tumours. From a database of 2526 tumours collected from 2003 to 2020, we conducted a longitudinal analysis of the main trends in diagnosis, age, multiplicity and anatomical distribution as well as a case-control study comparing these cases with the contemporaneous canine population of the Canary Archipelago to analyse breed distribution. In line with former studies, we found histiocytomas mostly affect young dogs (2, IQR 1-5) and mast cell tumours affect middle-to-old dogs (8, IQR 6-10) with grade 1 affecting at younger ages (6.5, IQR 6-8) than both grade 2 (8, IQR 6-10 years) and grade 3 (9, IQR 7-11). Histiocytomas and plasmacytomas showed a similar anatomical distribution appearing mainly on the face, head and neck regions while mast cell tumours occur mainly on limbs and trunk. Higher risk for mast cell tumours and histiocytomas were found for Bulldog-related breeds such as Boxer (ORMCT = 23.61, CI95%: 19.12-29.15, ORHCT = 10.17, CI95%: 6.60-15.67), Boston Terrier (ORMCT 19.47, CI95%: 7.73-49.05, ORHCT 32.61, CI95%: 11.81-90.07) and Pug (ORMCT 8.10, CI95%: 5.92-11.07, ORHCT 7.87, CI95%: 4.66-13.28) while Chihuahua dogs showed significantly less risk (ORMCT 0.18, CI95%: 0.09-0.33, ORHCT 0.41, CI95%: 0.21-0.78). Notably, the Canarian Mastiff, a local breed, had a low risk of suffering from a mast cell tumour which raises the question of whether this relates to a genetic peculiarity of this breed or some husbandry and environmental factor.
摘要：
在这项研究中，我们对西班牙加那利群岛（PTR-CA）的宠物肿瘤登记处进行了全面分析，以调查犬皮肤圆形细胞肿瘤的流行病学。从2003年至2020年收集的2526个肿瘤的数据库中，我们对诊断的主要趋势进行了纵向分析，年龄,多重性和解剖分布以及病例对照研究，将这些病例与加那利群岛的同期犬类种群进行比较，以分析品种分布。根据以前的研究，我们发现组织细胞瘤主要影响幼犬(2,IQR1-5),肥大细胞瘤影响中老年犬(8,IQR6-10),1级影响年龄较小(6.5,IQR6-8)的2级(8,IQR6-10岁)和3级(9,IQR7-11).组织细胞瘤和浆细胞瘤表现出相似的解剖分布，主要出现在面部，头部和颈部区域，而肥大细胞肿瘤主要发生在四肢和躯干。与斗牛犬相关的品种如Boxer（ORMCT=23.61，CI95％：19.12-29.15，ORHCT=10.17，CI95％：6.60-15.67），波士顿梗（ORMCT19.47，CI95％：7.73-49.05，ORHCT32.61，CI95％：11.81-90.07）和帕格（ORMCT8.10，CI95％：5.92-11.07，ORHCT7.87，CI95％：4.66-13.28），而奇瓦瓦犬的风险明显降低（ORMCT0.18，CI95％：0.09-0.41，0.值得注意的是,Canarianmast,一个当地的品种，患肥大细胞瘤的风险较低，这引发了一个问题，即这是否与该品种的遗传特性或某些饲养和环境因素有关。
