PDF(Pubmed)
Abstract：
Fetal and perinatal periods are critical phases for long-term development. Early diagnosis of maternal complications is challenging due to the great complexity of these conditions. In recent years, amniotic fluid has risen in a prominent position in the latest efforts to describe and characterize prenatal development. Amniotic fluid may provide real-time information on fetal development and metabolism throughout pregnancy as substances from the placenta, fetal skin, lungs, gastric fluid, and urine are transferred between the mother and the fetus. Applying metabolomics to monitor fetal well-being, in such a context, could help in the understanding, diagnosis, and treatment of these conditions and is a promising area of research. This review shines a spotlight on recent amniotic fluid metabolomics studies and their methods as an interesting tool for the assessment of many conditions and the identification of biomarkers. Platforms in use, such as proton nuclear magnetic resonance (1H NMR) and ultra-high-performance liquid chromatography (UHPLC), have different merits, and a combinatorial approach could be valuable. Metabolomics may also be used in the quest for habitual diet-induced metabolic signals in amniotic fluid. Finally, analysis of amniotic fluid can provide information on exposure to exogenous substances by detecting the exact levels of metabolites carried to the fetus and associated metabolic effects.
摘要：
胎儿和围产期是长期发展的关键阶段。由于这些疾病的复杂性，对母体并发症的早期诊断具有挑战性。近年来,羊水在描述和表征产前发育的最新努力中占据了突出的位置。羊水可以在整个怀孕期间提供有关胎儿发育和代谢的实时信息，作为来自胎盘的物质，胎儿皮肤,肺,胃液,尿液在母亲和胎儿之间转移。应用代谢组学监测胎儿健康，在这样的背景下,可以帮助理解，诊断,和治疗这些疾病，是一个有前途的研究领域。这篇综述聚焦了最近的羊水代谢组学研究及其方法，作为评估许多条件和鉴定生物标志物的有趣工具。使用中的平台,如质子核磁共振（1HNMR）和超高效液相色谱（UHPLC），有不同的优点，组合方法可能很有价值。代谢组学也可用于寻求羊水中习惯性饮食诱导的代谢信号。最后,羊水分析可以通过检测胎儿携带的代谢物的确切水平和相关的代谢作用来提供有关暴露于外源物质的信息。
