PDF(Pubmed)
Abstract：
Sibling female and male Chihuahuas were evaluated for a 9-month history of tachypnea that failed to respond to fenbendazole, doxycycline, amoxicillin-clavulanate, and prednisone. Physical examination identified tachypnea, hyperpnea, and harsh bronchovesicular lung sounds. Fundic examination disclosed diffuse chorioretinitis, manifested as multifocal chorioretinal granulomas in the female dog and occasional chorioretinal scars in the male dog. Thoracic radiographs indicated moderate to severe interstitial to broncho-interstitial infiltrates in both dogs. Serum and urine antigen and antibody testing in the female dog failed to identify infectious agents, but cytologic assessment of hepatic lymph node, liver, and splenic aspirates identified Pneumocystis trophozoites. Infection was confirmed in both dogs by 28S rRNA PCR sequencing from multiple tissue samples. The female dog responded well to trimethoprim-sulfamethoxazole, but the male dog was euthanized because of liver failure, presumably related to antimicrobial treatment.
摘要：
同胞女性和男性吉娃娃进行了9个月的呼吸急促史的评估，对芬苯达唑无反应，多西环素,阿莫西林-克拉维酸，和泼尼松。体格检查发现呼吸急促，呼吸过度,和刺耳的支气管泡状肺音.真菌检查发现弥漫性脉络膜视网膜炎，表现为雌性狗的多灶性脉络膜视网膜肉芽肿和雄性狗的偶发脉络膜视网膜疤痕。胸部X光片显示两只狗的中度至重度间质至支气管间质浸润。母犬的血清和尿液抗原和抗体检测未能确定感染因子，但是肝淋巴结的细胞学评估，肝脏,脾抽吸物鉴定了肺孢子虫滋养体。通过来自多个组织样品的28SrRNAPCR测序在两只狗中确认感染。雌性狗对甲氧苄啶-磺胺甲恶唑反应良好，但是雄狗因为肝功能衰竭而被安乐死,可能与抗菌治疗有关。
