Abstract：
BACKGROUND: Topical retinoids are a mainstay in acne management and have been shown to improve skin texture. Injectable non-animal stabilized hyaluronic acid (NASHATM) gel as skin booster is largely used in aesthetic treatments to improve skin quality including the appearance of atrophic acne scars.
OBJECTIVE: To evaluate a new sequential treatment with topical trifarotene and injectable skin booster NASHA gel in acne scars.
METHODS: 10 patients between 19 and 25 years (3 males and 7 females) with previous moderate to severe acne vulgaris on the face with the outcome of atrophic and post-inflammatory slightly hyperpigmented scars were prescribed home short contact therapy (SCT) with topical trifarotene 50 μg/g at the evening for 3 months. A proper skincare routine for sensitive skin was also recommended. The 3-month retinoid therapy was followed by an injectable medical procedure with NASHA gel 20 mg/ml as skin booster. A minimum of 3 sessions to 10 sessions were carried out according to the severity of acne scars and the skin response observed.
RESULTS: Adherence to the treatment was complete and the results evaluated by digital photography showed very effective results with high clinical improvement or almost complete resolution of atrophic acne scars.
CONCLUSIONS: The results observed in this case series show that the sequential treatment with topical trifarotene and injectable NASHA gel as skin booster can be effective in the progressive reduction of acne scarring, potentially related to a synergic effect of skin remodeling and collagen stimulation. J Drugs Dermatol. 2023;22(5): doi:10.36849/JDD.7630.
OBJECTIVE: To evaluate a new sequential treatment with topical trifarotene and injectable skin booster NASHA gel in acne scars.
METHODS: 10 patients between 19 and 25 years (3 males and 7 females) with previous moderate to severe acne vulgaris on the face with the outcome of atrophic and post-inflammatory slightly hyperpigmented scars were prescribed home short contact therapy (SCT) with topical trifarotene 50 μg/g at the evening for 3 months. A proper skincare routine for sensitive skin was also recommended. The 3-month retinoid therapy was followed by an injectable medical procedure with NASHA gel 20 mg/ml as skin booster. A minimum of 3 sessions to 10 sessions were carried out according to the severity of acne scars and the skin response observed.
RESULTS: Adherence to the treatment was complete and the results evaluated by digital photography showed very effective results with high clinical improvement or almost complete resolution of atrophic acne scars.
CONCLUSIONS: The results observed in this case series show that the sequential treatment with topical trifarotene and injectable NASHA gel as skin booster can be effective in the progressive reduction of acne scarring, potentially related to a synergic effect of skin remodeling and collagen stimulation. J Drugs Dermatol. 2023;22(5): doi:10.36849/JDD.7630.
摘要：
背景：外用类维生素A是痤疮治疗的主要方法，并已被证明可以改善皮肤质地。作为皮肤增强剂的可注射非动物稳定的透明质酸(NASHATM)凝胶主要用于美容治疗以改善皮肤质量,包括萎缩性痤疮疤痕的出现。
目的：评价一种新的局部三法罗汀和可注射皮肤增强剂NASHA凝胶序贯治疗痤疮疤痕。
方法：10名年龄在19至25岁之间的患者（3名男性和7名女性）患有面部中度至重度寻常性痤疮，并伴有萎缩性和炎症后轻度色素沉着疤痕，在晚上进行家庭短期接触治疗（SCT），并局部使用三法罗汀50μg/g。3个月。还建议对敏感皮肤进行适当的护肤。3个月的类视黄醇治疗之后是使用NASHA凝胶20mg/ml作为皮肤增强剂的可注射医疗程序。根据痤疮疤痕的严重程度和观察到的皮肤反应，至少进行3次至10次。
结果：对治疗的坚持是完全的，通过数字摄影评估的结果显示出非常有效的结果，萎缩性痤疮疤痕的临床改善或几乎完全消退。
结论：在本病例系列中观察到的结果表明，使用局部三法罗汀和可注射的NASHA凝胶作为皮肤增强剂的序贯治疗可以有效地逐渐减少痤疮疤痕，可能与皮肤重塑和胶原蛋白刺激的协同作用有关。J药物Dermatol.2023年；22（5）：doi：10.36849/JD.7630。
目的：评价一种新的局部三法罗汀和可注射皮肤增强剂NASHA凝胶序贯治疗痤疮疤痕。
方法：10名年龄在19至25岁之间的患者（3名男性和7名女性）患有面部中度至重度寻常性痤疮，并伴有萎缩性和炎症后轻度色素沉着疤痕，在晚上进行家庭短期接触治疗（SCT），并局部使用三法罗汀50μg/g。3个月。还建议对敏感皮肤进行适当的护肤。3个月的类视黄醇治疗之后是使用NASHA凝胶20mg/ml作为皮肤增强剂的可注射医疗程序。根据痤疮疤痕的严重程度和观察到的皮肤反应，至少进行3次至10次。
结果：对治疗的坚持是完全的，通过数字摄影评估的结果显示出非常有效的结果，萎缩性痤疮疤痕的临床改善或几乎完全消退。
结论：在本病例系列中观察到的结果表明，使用局部三法罗汀和可注射的NASHA凝胶作为皮肤增强剂的序贯治疗可以有效地逐渐减少痤疮疤痕，可能与皮肤重塑和胶原蛋白刺激的协同作用有关。J药物Dermatol.2023年；22（5）：doi：10.36849/JD.7630。
