PDF(Pubmed)
Abstract：
New psychoactive substances continue to appear on the drug market, and alpha-pyrrolidinoisohexanophenone (α-PiHP) is one of the most popular cathinone derivatives. In this article, we report a case of death caused by α-PiHP. Based on the toxicological results of the studied case along with autopsy, histopathological findings and crime-scene information, fatal intoxication with α-PiHP was accepted as the final cause of death. α-PiHP and its metabolite (OH-α-PiHP) were detected and quantified in all postmortem materials (blood collected from the heart, the femoral vein and the dural venous sinuses; vitreous humor; cerebrospinal fluid; cerebral cortex; brainstem; cerebellum; bile; liver; kidney; heart; pancreas; spleen; thyroid gland; lung; adipose tissue; stomach and intestine). To date, this is the first case of determination of α-PiHP and its metabolite in postmortem specimens. In our opinion, α-PiHP and its metabolite concentration database can be helpful in the interpretation of fatal cases.
摘要：
新的精神活性物质（NPS）继续出现在药物市场上，α-吡咯烷基异己酮（α-PiHP）是最受欢迎的卡西酮衍生物之一。在本文中,我们报告了一例由α-PiHP引起的死亡病例。根据所研究病例的毒理学结果以及尸检，组织病理学发现和犯罪现场信息，α-PiHP致命性中毒被认为是最终死亡原因.α-PiHP及其代谢物（OH-α-PiHP）在所有死后材料（从心脏收集的血液，股静脉和硬脑膜静脉窦,玻璃体幽默,脑脊液,大脑皮层,脑干,小脑,胆汁,肝脏,肾,心,胰腺,脾,脾甲状腺,肺，脂肪组织,胃和肠）。迄今为止,这是首次在尸检标本中测定α-PiHP及其代谢物。在我们看来,α-PiHP及其代谢物浓度数据库有助于解释致命病例。
