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Abstract：
Many digestive system malignant tumors are characterized by high incidence and mortality rate. Increasing evidence has revealed that the tumor microenvironment (TME) is involved in cancer initiation and tumor progression. Tumor-associated macrophages (TAMs) are a predominant constituent of the TME, and participate in the regulation of various biological behaviors and influence the prognosis of digestive system cancer. TAMs can be mainly classified into the antitumor M1 phenotype and protumor M2 phenotype. The latter especially are crucial drivers of tumor invasion, growth, angiogenesis, metastasis, immunosuppression, and resistance to therapy. TAMs are of importance in the occurrence, development, diagnosis, prognosis, and treatment of common digestive system malignant tumors. In this review, we summarize the role of TAMs in common digestive system malignant tumors, including esophageal, gastric, colorectal, pancreatic and liver cancers. How TAMs promote the development of tumors, and how they act as potential therapeutic targets and their clinical applications are also described.
摘要：
许多消化系统恶性肿瘤的特点是发病率和死亡率高。越来越多的证据表明，肿瘤微环境（TME）与癌症的发生和发展有关。肿瘤相关巨噬细胞（TAM）是TME的主要组成部分，参与各种生物学行为的调控,影响消化系统肿瘤的预后。TAMs主要可分为抗肿瘤M1表型和原瘤M2表型。后者尤其是肿瘤侵袭的关键驱动因素，增长,血管生成,转移,免疫抑制,和对治疗的抵抗力。TAM在发生中很重要，发展,诊断,预后,及常见消化系统恶性肿瘤的治疗。在这次审查中,我们总结了TAMs在常见消化系统恶性肿瘤中的作用，包括食道,胃,结直肠,胰腺癌和肝癌。TAM如何促进肿瘤的发展，以及它们如何作为潜在的治疗靶点和它们的临床应用也被描述。
