PDF(Pubmed)
Abstract：
UNASSIGNED: To provide a concise review on risk factors, stages, pathophysiology, prevention and possible treatment options for both MRONJ and ORN individually.
UNASSIGNED: The review was conducted according to the \'Preferred Reporting Items for Systematic Reviews and Meta-Analyses\' (PRISMA) guidelines. A comprehensive search of the PUBMED, Ebsco, SCOPUS, WEB OF SCIENCE and NDH for articles published up until 2021 was performed. After screening and full text analyses, 44 studies were included in this review. Definition, risk factors, etiology, symptoms, stages, pathophysiology, prevention and possible management options were explored and highlighted in this article.
UNASSIGNED: Three studies described osteonecrosis of jaw (ONJ) in general, 15 studies described ONJ associated with radiotherapy and 26 studies described ONJ associated with medications. Both the two conditions (ORN) and (MRONJ) have relatively similar clinical presentations clearing the fact that a resemblance in clinical presentations does not necessarily denote a similar pathophysiology.
UNASSIGNED: However, various advancements have been made in the control and management of ONJ, but until and unless need for high tumoricidal doses exists, ONJ will certainly continue to remain as a clinical challenge demanding satisfactory treatment to improve the quality of life of the patient.
UNASSIGNED: The review was conducted according to the \'Preferred Reporting Items for Systematic Reviews and Meta-Analyses\' (PRISMA) guidelines. A comprehensive search of the PUBMED, Ebsco, SCOPUS, WEB OF SCIENCE and NDH for articles published up until 2021 was performed. After screening and full text analyses, 44 studies were included in this review. Definition, risk factors, etiology, symptoms, stages, pathophysiology, prevention and possible management options were explored and highlighted in this article.
UNASSIGNED: Three studies described osteonecrosis of jaw (ONJ) in general, 15 studies described ONJ associated with radiotherapy and 26 studies described ONJ associated with medications. Both the two conditions (ORN) and (MRONJ) have relatively similar clinical presentations clearing the fact that a resemblance in clinical presentations does not necessarily denote a similar pathophysiology.
UNASSIGNED: However, various advancements have been made in the control and management of ONJ, but until and unless need for high tumoricidal doses exists, ONJ will certainly continue to remain as a clinical challenge demanding satisfactory treatment to improve the quality of life of the patient.
摘要：
■为了提供对风险因素的简要审查，阶段,病理生理学,MRONJ和ORN的预防和可能的治疗选择。
审查是根据“系统审查和荟萃分析的首选报告项目”（PRISMA）指南进行的。全面搜索PUBMED，Ebsco,Scopus,发表到2021年的文章的《科学和NDH》。经过筛选和全文分析，44项研究纳入本综述。定义,危险因素，病因学,症状,阶段,病理生理学,本文探讨并强调了预防和可能的管理方案。
■三项研究总体上描述了颌骨坏死（ONJ），15项研究描述了与放疗相关的ONJ，26项研究描述了与药物相关的ONJ。这两种情况（ORN）和（MRONJ）都具有相对相似的临床表现，这清楚了以下事实：临床表现的相似性并不一定表示相似的病理生理学。
■然而，在ONJ的控制和管理方面取得了各种进步，但是直到并且除非需要高的杀肿瘤剂量，ONJ肯定会继续作为临床挑战，需要令人满意的治疗来改善患者的生活质量。
审查是根据“系统审查和荟萃分析的首选报告项目”（PRISMA）指南进行的。全面搜索PUBMED，Ebsco,Scopus,发表到2021年的文章的《科学和NDH》。经过筛选和全文分析，44项研究纳入本综述。定义,危险因素，病因学,症状,阶段,病理生理学,本文探讨并强调了预防和可能的管理方案。
■三项研究总体上描述了颌骨坏死（ONJ），15项研究描述了与放疗相关的ONJ，26项研究描述了与药物相关的ONJ。这两种情况（ORN）和（MRONJ）都具有相对相似的临床表现，这清楚了以下事实：临床表现的相似性并不一定表示相似的病理生理学。
■然而，在ONJ的控制和管理方面取得了各种进步，但是直到并且除非需要高的杀肿瘤剂量，ONJ肯定会继续作为临床挑战，需要令人满意的治疗来改善患者的生活质量。
