PDF(Pubmed)
Abstract：
BACKGROUND: Granular Cell Odontogenic Fibroma (GCOF) is a rare odontogenic neoplasm reported over time with different names. The purpose of this study is to review all available data on the GCOF in the scientific literature, with a summary of all reported cases and a report of a new case.
METHODS: This review was conducted following the PRISMA guidelines. An electronic search was performed up to November 2022.
RESULTS: Thirty-nine studies reporting fifty-three cases were included. GCOF is a rare neoplasm among the odontogenic tumors, with a higher prevalence in women of the middle-aged and white population. This lesion occurs mostly on the posterior region of the mandible. Furthermore, based on clinical, radiographic, and histopathologic features, conservative treatment was the most reported choice with recurrence reported in two cases.
CONCLUSIONS: GCOF remains controversial due to the still unsolved histogenesis.
METHODS: This review was conducted following the PRISMA guidelines. An electronic search was performed up to November 2022.
RESULTS: Thirty-nine studies reporting fifty-three cases were included. GCOF is a rare neoplasm among the odontogenic tumors, with a higher prevalence in women of the middle-aged and white population. This lesion occurs mostly on the posterior region of the mandible. Furthermore, based on clinical, radiographic, and histopathologic features, conservative treatment was the most reported choice with recurrence reported in two cases.
CONCLUSIONS: GCOF remains controversial due to the still unsolved histogenesis.
摘要：
背景：颗粒细胞牙源性纤维瘤（GCOF）是一种罕见的牙源性肿瘤，随着时间的推移有不同的名称。这项研究的目的是回顾科学文献中有关GCOF的所有可用数据，所有报告病例的摘要和新病例的报告。
方法：本综述遵循PRISMA指南进行。截至2022年11月，进行了电子搜索。
结果：纳入报告53例病例的39项研究。GCOF是牙源性肿瘤中的一种罕见肿瘤，在中年和白人女性中患病率较高。这种病变主要发生在下颌骨的后部。此外，基于临床，射线照相,和组织病理学特征，保守治疗是报告最多的选择,2例报告复发.
结论：由于尚未解决的组织发生，GCOF仍然存在争议。
方法：本综述遵循PRISMA指南进行。截至2022年11月，进行了电子搜索。
结果：纳入报告53例病例的39项研究。GCOF是牙源性肿瘤中的一种罕见肿瘤，在中年和白人女性中患病率较高。这种病变主要发生在下颌骨的后部。此外，基于临床，射线照相,和组织病理学特征，保守治疗是报告最多的选择,2例报告复发.
结论：由于尚未解决的组织发生，GCOF仍然存在争议。
