PubMed, Medline, Embase, Web of Science databases, and the Cochrane Library were searched up to August 12th 2022 for eligible studies. The urolithiasis patients were summarized into two groups: BMI < 25 and ≥ 25 kg/m2. Summary weighted mean difference (WMD), relative risk (RR) and 95% confidence intervals (CI) were calculated through random effects models in RevMan 5.4 software.
A total of fifteen studies involving 13,233 patients were enrolled in this meta-analysis. There was no significant correlation of BMI and size of urinary stone (WMD -0.13mm, 95% CI [-0.98, 0.73], p = 0.77). Overweight and obesity increased the risk of uric acid stones in both genders and in different regions (RR=0.87, [95% CI] = 0.83, 0.91, p<0.00001). There was a higher risk of calcium oxalate stones formation in overweight and obesity group in total patients (RR=0.95, [95% CI] = 0.91, 0.98, p = 0.006). The relationship of BMI and calcium phosphate was not observed in this meta-analysis (RR=1.12, [95% CI] = 0.98, 1.26, p = 0.09). Sensitivity analysis was performed and indicated similar results.
The current evidence suggests a positive association between BMI and uric acid and calcium oxalate stones. It would be of great guiding significance to consider losing weight when treating and preventing urinary stones.
方法:PubMed,Medline,Embase,WebofScience数据库,并在2022年8月12日之前对Cochrane图书馆进行了搜索,以获得符合条件的研究。将尿石症患者分为两组:BMI<25和≥25kg/m2。汇总加权平均差(WMD),通过RevMan5.4软件中的随机效应模型计算相对危险度(RR)和95%置信区间(CI).
结果:本荟萃分析共纳入15项研究,涉及13,233例患者。BMI与尿路结石大小无显著相关性(WMD-0.13mm,95%CI[-0.98,0.73],p=0.77)。超重和肥胖增加了不同性别和不同地区的尿酸结石风险(RR=0.87,[95%CI]=0.83,0.91,p<0.00001)。超重和肥胖组的草酸钙结石形成风险较高(RR=0.95,[95%CI]=0.91,0.98,p=0.006)。在该荟萃分析中未观察到BMI与磷酸钙的关系(RR=1.12,[95%CI]=0.98,1.26,p=0.09)。进行了敏感性分析,并显示了类似的结果。
结论:目前的证据表明BMI与尿酸和草酸钙结石之间呈正相关。在治疗和预防泌尿系结石时考虑减肥将具有重要的指导意义。