PDF(Pubmed)
Abstract：
Several studies have explored the impact of BMI on size and composition of urinary stones. Because there were controversies, a meta-analysis was necessary to be carried out to provide some evidence of the relationship of BMI and urolithiasis.
PubMed, Medline, Embase, Web of Science databases, and the Cochrane Library were searched up to August 12th 2022 for eligible studies. The urolithiasis patients were summarized into two groups: BMI < 25 and ≥ 25 kg/m2. Summary weighted mean difference (WMD), relative risk (RR) and 95% confidence intervals (CI) were calculated through random effects models in RevMan 5.4 software.
A total of fifteen studies involving 13,233 patients were enrolled in this meta-analysis. There was no significant correlation of BMI and size of urinary stone (WMD -0.13mm, 95% CI [-0.98, 0.73], p = 0.77). Overweight and obesity increased the risk of uric acid stones in both genders and in different regions (RR=0.87, [95% CI] = 0.83, 0.91, p<0.00001). There was a higher risk of calcium oxalate stones formation in overweight and obesity group in total patients (RR=0.95, [95% CI] = 0.91, 0.98, p = 0.006). The relationship of BMI and calcium phosphate was not observed in this meta-analysis (RR=1.12, [95% CI] = 0.98, 1.26, p = 0.09). Sensitivity analysis was performed and indicated similar results.
The current evidence suggests a positive association between BMI and uric acid and calcium oxalate stones. It would be of great guiding significance to consider losing weight when treating and preventing urinary stones.
PubMed, Medline, Embase, Web of Science databases, and the Cochrane Library were searched up to August 12th 2022 for eligible studies. The urolithiasis patients were summarized into two groups: BMI < 25 and ≥ 25 kg/m2. Summary weighted mean difference (WMD), relative risk (RR) and 95% confidence intervals (CI) were calculated through random effects models in RevMan 5.4 software.
A total of fifteen studies involving 13,233 patients were enrolled in this meta-analysis. There was no significant correlation of BMI and size of urinary stone (WMD -0.13mm, 95% CI [-0.98, 0.73], p = 0.77). Overweight and obesity increased the risk of uric acid stones in both genders and in different regions (RR=0.87, [95% CI] = 0.83, 0.91, p<0.00001). There was a higher risk of calcium oxalate stones formation in overweight and obesity group in total patients (RR=0.95, [95% CI] = 0.91, 0.98, p = 0.006). The relationship of BMI and calcium phosphate was not observed in this meta-analysis (RR=1.12, [95% CI] = 0.98, 1.26, p = 0.09). Sensitivity analysis was performed and indicated similar results.
The current evidence suggests a positive association between BMI and uric acid and calcium oxalate stones. It would be of great guiding significance to consider losing weight when treating and preventing urinary stones.
摘要：
背景：一些研究探讨了BMI对尿路结石大小和成分的影响。因为有争议，需要进行荟萃分析,以提供BMI与尿石症关系的一些证据.
方法：PubMed，Medline,Embase,WebofScience数据库,并在2022年8月12日之前对Cochrane图书馆进行了搜索，以获得符合条件的研究。将尿石症患者分为两组：BMI<25和≥25kg/m2。汇总加权平均差(WMD)，通过RevMan5.4软件中的随机效应模型计算相对危险度(RR)和95%置信区间(CI).
结果：本荟萃分析共纳入15项研究，涉及13,233例患者。BMI与尿路结石大小无显著相关性(WMD-0.13mm,95%CI[-0.98，0.73]，p=0.77）。超重和肥胖增加了不同性别和不同地区的尿酸结石风险(RR=0.87,[95%CI]=0.83,0.91,p<0.00001)。超重和肥胖组的草酸钙结石形成风险较高(RR=0.95,[95%CI]=0.91,0.98,p=0.006)。在该荟萃分析中未观察到BMI与磷酸钙的关系（RR=1.12，[95％CI]=0.98，1.26，p=0.09）。进行了敏感性分析，并显示了类似的结果。
结论：目前的证据表明BMI与尿酸和草酸钙结石之间呈正相关。在治疗和预防泌尿系结石时考虑减肥将具有重要的指导意义。
方法：PubMed，Medline,Embase,WebofScience数据库,并在2022年8月12日之前对Cochrane图书馆进行了搜索，以获得符合条件的研究。将尿石症患者分为两组：BMI<25和≥25kg/m2。汇总加权平均差(WMD)，通过RevMan5.4软件中的随机效应模型计算相对危险度(RR)和95%置信区间(CI).
结果：本荟萃分析共纳入15项研究，涉及13,233例患者。BMI与尿路结石大小无显著相关性(WMD-0.13mm,95%CI[-0.98，0.73]，p=0.77）。超重和肥胖增加了不同性别和不同地区的尿酸结石风险(RR=0.87,[95%CI]=0.83,0.91,p<0.00001)。超重和肥胖组的草酸钙结石形成风险较高(RR=0.95,[95%CI]=0.91,0.98,p=0.006)。在该荟萃分析中未观察到BMI与磷酸钙的关系（RR=1.12，[95％CI]=0.98，1.26，p=0.09）。进行了敏感性分析，并显示了类似的结果。
结论：目前的证据表明BMI与尿酸和草酸钙结石之间呈正相关。在治疗和预防泌尿系结石时考虑减肥将具有重要的指导意义。
