UNASSIGNED: We recruited 40 patients with FMD, 53 with RMD, and 38 healthy controls (HCs) from May 2021 to April 2022. Symptom severity was assessed with the 24-item Hamilton Depression Rating Scale (HAM-D) and the Hamilton Anxiety Rating Scale (HAM-A). A 52-channel fNIRS measured changes in [oxy-Hb] during VFT performance.
UNASSIGNED: Both patient groups performed poorly during the VFT task compared with HC (FDR p < 0.05), but there was no significant difference between the two patient groups. Analysis of variance showed that mean [oxy-Hb] activation was lower in both the frontal and temporal lobes in the MDD group compared with HCs (FDR p < 0.05). Additionally, patients with RMD had a significantly lower hemodynamic response in the right dorsolateral prefrontal cortex (DLPFC) and dorsal frontal pole cortex (DFPC) than patients with FMD (FDR p < 0.05). No significant correlation was found between changes in mean [oxy-Hb] and either medical history or clinical symptoms (FDR p < 0.05).
UNASSIGNED: The presence of different neurofunctional activity in some of the same brain regions in FMD and RMD patients implied a link between the level of complexity activation in frontal regions and the stage of MDD. Cognitive impairment may already be present at the beginning of an MDD episode.
UNASSIGNED: www.chictr.org.cn, identifier ChiCTR2100043432.
■我们招募了40名FMD患者,53与RMD,和2021年5月至2022年4月的38名健康对照(HCs)。使用24项汉密尔顿抑郁量表(HAM-D)和汉密尔顿焦虑量表(HAM-A)评估症状严重程度。52通道fNIRS测量了VFT性能期间[oxy-Hb]的变化。
■两组患者在VFT任务期间的表现均低于HC(FDRp<0.05),但是两组患者之间没有显着差异。方差分析显示,与HC相比,MDD组的额叶和颞叶的平均[oxy-Hb]激活均较低(FDRp<0.05)。此外,与FMD患者相比,RMD患者的右背外侧前额叶皮质(DLPFC)和背额叶皮质(DFPC)的血流动力学反应显着降低(FDRp<0.05)。在平均[oxy-Hb]的变化与病史或临床症状之间没有发现显着相关性(FDRp<0.05)。
■在FMD和RMD患者的某些相同大脑区域中存在不同的神经功能活动,这意味着额叶区域的复杂性激活水平与MDD的分期之间存在联系。在MDD发作开始时可能已经存在认知障碍。
■www.chictr.org.cn,标识符ChiCTR2100043432。