PDF(Pubmed)
Abstract：
UNASSIGNED: Functional near-infrared spectroscopy (fNIRS) identifies neurophysiological differences between psychiatric disorders by assessing cortical hemodynamic function. Few trials have studied differences in brain functional activity between first-episode medication-naïve depression patients (FMD) and recurrent major depression (RMD). We aimed to determine the differences between FMD and RMD in oxygenated hemoglobin concentration ([oxy-Hb]), and to investigate the correlation between frontotemporal cortex activation and clinical symptoms.
UNASSIGNED: We recruited 40 patients with FMD, 53 with RMD, and 38 healthy controls (HCs) from May 2021 to April 2022. Symptom severity was assessed with the 24-item Hamilton Depression Rating Scale (HAM-D) and the Hamilton Anxiety Rating Scale (HAM-A). A 52-channel fNIRS measured changes in [oxy-Hb] during VFT performance.
UNASSIGNED: Both patient groups performed poorly during the VFT task compared with HC (FDR p < 0.05), but there was no significant difference between the two patient groups. Analysis of variance showed that mean [oxy-Hb] activation was lower in both the frontal and temporal lobes in the MDD group compared with HCs (FDR p < 0.05). Additionally, patients with RMD had a significantly lower hemodynamic response in the right dorsolateral prefrontal cortex (DLPFC) and dorsal frontal pole cortex (DFPC) than patients with FMD (FDR p < 0.05). No significant correlation was found between changes in mean [oxy-Hb] and either medical history or clinical symptoms (FDR p < 0.05).
UNASSIGNED: The presence of different neurofunctional activity in some of the same brain regions in FMD and RMD patients implied a link between the level of complexity activation in frontal regions and the stage of MDD. Cognitive impairment may already be present at the beginning of an MDD episode.
UNASSIGNED: www.chictr.org.cn, identifier ChiCTR2100043432.
UNASSIGNED: We recruited 40 patients with FMD, 53 with RMD, and 38 healthy controls (HCs) from May 2021 to April 2022. Symptom severity was assessed with the 24-item Hamilton Depression Rating Scale (HAM-D) and the Hamilton Anxiety Rating Scale (HAM-A). A 52-channel fNIRS measured changes in [oxy-Hb] during VFT performance.
UNASSIGNED: Both patient groups performed poorly during the VFT task compared with HC (FDR p < 0.05), but there was no significant difference between the two patient groups. Analysis of variance showed that mean [oxy-Hb] activation was lower in both the frontal and temporal lobes in the MDD group compared with HCs (FDR p < 0.05). Additionally, patients with RMD had a significantly lower hemodynamic response in the right dorsolateral prefrontal cortex (DLPFC) and dorsal frontal pole cortex (DFPC) than patients with FMD (FDR p < 0.05). No significant correlation was found between changes in mean [oxy-Hb] and either medical history or clinical symptoms (FDR p < 0.05).
UNASSIGNED: The presence of different neurofunctional activity in some of the same brain regions in FMD and RMD patients implied a link between the level of complexity activation in frontal regions and the stage of MDD. Cognitive impairment may already be present at the beginning of an MDD episode.
UNASSIGNED: www.chictr.org.cn, identifier ChiCTR2100043432.
摘要：
■功能近红外光谱（fNIRS）通过评估皮质血液动力学功能来鉴定精神疾病之间的神经生理学差异。很少有试验研究首发药物初治抑郁症患者（FMD）和复发性重度抑郁症（RMD）之间脑功能活动的差异。我们旨在确定FMD和RMD在氧合血红蛋白浓度（[oxy-Hb]）中的差异，探讨额颞叶皮层激活与临床症状的相关性。
■我们招募了40名FMD患者，53与RMD，和2021年5月至2022年4月的38名健康对照(HCs)。使用24项汉密尔顿抑郁量表（HAM-D）和汉密尔顿焦虑量表（HAM-A）评估症状严重程度。52通道fNIRS测量了VFT性能期间[oxy-Hb]的变化。
■两组患者在VFT任务期间的表现均低于HC（FDRp<0.05），但是两组患者之间没有显着差异。方差分析显示，与HC相比，MDD组的额叶和颞叶的平均[oxy-Hb]激活均较低（FDRp<0.05）。此外,与FMD患者相比，RMD患者的右背外侧前额叶皮质（DLPFC）和背额叶皮质（DFPC）的血流动力学反应显着降低（FDRp<0.05）。在平均[oxy-Hb]的变化与病史或临床症状之间没有发现显着相关性（FDRp<0.05）。
■在FMD和RMD患者的某些相同大脑区域中存在不同的神经功能活动，这意味着额叶区域的复杂性激活水平与MDD的分期之间存在联系。在MDD发作开始时可能已经存在认知障碍。
■www.chictr.org.cn,标识符ChiCTR2100043432。
■我们招募了40名FMD患者，53与RMD，和2021年5月至2022年4月的38名健康对照(HCs)。使用24项汉密尔顿抑郁量表（HAM-D）和汉密尔顿焦虑量表（HAM-A）评估症状严重程度。52通道fNIRS测量了VFT性能期间[oxy-Hb]的变化。
■两组患者在VFT任务期间的表现均低于HC（FDRp<0.05），但是两组患者之间没有显着差异。方差分析显示，与HC相比，MDD组的额叶和颞叶的平均[oxy-Hb]激活均较低（FDRp<0.05）。此外,与FMD患者相比，RMD患者的右背外侧前额叶皮质（DLPFC）和背额叶皮质（DFPC）的血流动力学反应显着降低（FDRp<0.05）。在平均[oxy-Hb]的变化与病史或临床症状之间没有发现显着相关性（FDRp<0.05）。
■在FMD和RMD患者的某些相同大脑区域中存在不同的神经功能活动，这意味着额叶区域的复杂性激活水平与MDD的分期之间存在联系。在MDD发作开始时可能已经存在认知障碍。
■www.chictr.org.cn,标识符ChiCTR2100043432。
