PDF(Pubmed)
Abstract：
Systemic lupus erythematosus (SLE) is an autoimmune disease, which has been associated with Epstein-Barr virus (EBV) and Cytomegalovirus (CMV) infection. Drug-induced lupus (DIL) is a lupus-like disease caused by the intake of therapeutic drugs, which has been estimated to cause approximately 10-15% of lupus-like cases. Although SLE and DIL share common clinical symptoms, there are some fundamental differences between DIL and SLE onset. Moreover, it remains to be examined whether environmental factors, such as EBV and CMV infections, may contribute to the development of DIL. This study focused on examining the possible association between DIL and EBV and CMV infections, by examining IgG titers to EBV and CMV antigens in serum samples by enzyme-linked immunosorbent assays. Antibody titers to EBV early antigen-diffuse and CMV pp52 were found to be significantly elevated in both SLE and DIL patients compared to healthy controls, although no correlation was found for antibodies to the two virus antigens in the respective disease groups. Moreover, total IgG titers were reduced in SLE and DIL serum samples, which may reflect a general lymphocytopenia, which commonly is associated with SLE. The current findings support that EBV and CMV infections may contribute to the development of DIL and that onset of both diseases are related.
摘要：
系统性红斑狼疮（SLE）是一种自身免疫性疾病，与EB病毒（EBV）和巨细胞病毒（CMV）感染有关。药物性狼疮(DIL)是一种因摄入治疗药物而引起的狼疮样疾病,据估计，这导致了大约10-15%的狼疮样病例。尽管SLE和DIL具有共同的临床症状，DIL和SLE发病之间存在一些根本差异。此外，环境因素，如EBV和CMV感染，可能有助于DIL的发展。这项研究的重点是检查DIL和EBV与CMV感染之间的可能关联，通过酶联免疫吸附试验检测血清样品中EBV和CMV抗原的IgG滴度。与健康对照相比，SLE和DIL患者对EBV早期抗原扩散和CMVpp52的抗体滴度显着升高。尽管在各自的疾病组中未发现针对两种病毒抗原的抗体存在相关性。此外，SLE和DIL血清样品中的总IgG滴度降低，这可能反映了一般的淋巴细胞减少症，这通常与SLE有关。目前的发现支持EBV和CMV感染可能有助于DIL的发展，并且这两种疾病的发作是相关的。
