PDF(Pubmed)
Abstract：
Sever fever with thrombocytopenia syndrome (SFTS) is a new infectious disease that has emerged in recent years and is widely distributed, highly contagious, and lethal, with a mortality rate of up to 30%, especially in people with immune system deficiencies and elderly patients. SFTS is an insidious, negative-stranded RNA virus that has a major public health impact worldwide. The development of a vaccine and the hunt for potent therapeutic drugs are crucial to the prevention and treatment of Bunyavirus infection because there is no particular treatment for SFTS. In this respect, investigating the mechanics of SFTS-host cell interactions is crucial for creating antiviral medications. In the present paper, we summarized the mechanism of interaction between SFTS and pattern recognition receptors, endogenous antiviral factors, inflammatory factors, and immune cells. Furthermore, we summarized the current therapeutic drugs used for SFTS treatment, aiming to provide a theoretical basis for the development of targets and drugs against SFTS.
摘要：
发热伴血小板减少综合征(SFTS)是近年来出现的一种分布广泛的新型传染病,高度传染性，和致命的，死亡率高达30%，尤其是免疫系统缺陷的人和老年患者。SFTS是一个阴险的人，负链RNA病毒，在全球范围内对公共卫生产生重大影响。疫苗的开发和寻找有效的治疗药物对于预防和治疗布尼亚病毒感染至关重要，因为SFTS没有特殊的治疗方法。在这方面,研究SFTS-宿主细胞相互作用的机制对于创建抗病毒药物至关重要。在本论文中，我们总结了SFTS与模式识别受体相互作用的机制，内源性抗病毒因子，炎症因子，和免疫细胞。此外，我们总结了目前用于SFTS治疗的治疗药物，旨在为开发抗SFTS的靶点和药物提供理论依据。
