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Abstract：
Background: Chronic kidney disease (CKD) has various etiologies, making it impossible to fully understand its complex pathophysiology. Elevated levels of plasma creatinine, proteinuria, and albuminuria and declined eGFR are traits observed in CKD patients. The current study attempts to highlight the collagen triple helix repeat containing 1 (CTHRC1) protein as a putative blood biomarker for CKD in addition to existing recognized indicators of CKD progression. Methods: A total of 26 CKD patients and 18 healthy controls were enrolled in this study. Clinical characteristics and complete blood and biochemical analyses were collected, and human ELISA kits were used to detect possible CKD biomarkers. Results: The study\'s findings showed that CTHRC1 correlates with key clinical markers of kidney function such as 24 h urine total protein, creatinine, urea, and uric acid. In addition, CTHRC1 demonstrated a strong significant difference (p ≤ 0.0001) between the CKD and control group. Conclusions: Our research demonstrates that the plasma level of CTHRC1 can distinguish between those with CKD and healthy patients. Plasma CTHRC1 levels may aid in the diagnosis of CKD given the current state of knowledge, and these results call for further investigation in a wider, more diverse patient group.
摘要：
背景：慢性肾脏病（CKD）有多种病因，无法完全理解其复杂的病理生理学。血浆肌酐水平升高,蛋白尿,蛋白尿和eGFR下降是CKD患者的特征。目前的研究试图强调胶原蛋白三螺旋重复1（CTHRC1）蛋白作为CKD的推定血液生物标志物，除了现有的公认的CKD进展指标。方法:26例CKD患者和18例健康对照者纳入研究。收集临床特征和全血和生化分析，和人ELISA试剂盒用于检测可能的CKD生物标志物。结果：研究结果表明，CTHRC1与肾功能的关键临床指标如24h尿总蛋白相关，肌酐,尿素,和尿酸。此外,CTHRC1在CKD组和对照组之间表现出显著差异(p≤0.0001)。结论：我们的研究表明，血浆CTHRC1水平可以区分CKD患者和健康患者。鉴于目前的知识状况，血浆CTHRC1水平可能有助于CKD的诊断，这些结果需要在更广泛的范围内进行进一步的调查，更多样化的患者群体。
