METHODS: Using the search terms (\"Cardiac cycle\" OR \"echocardiography\" OR \"LVET\" OR \"IVCT\" OR \"IVRT\" OR \"LVEF\" OR \"Systolic Dysfunction\" OR \"Diastolic Dysfunction\") AND (\"Parkinson\'s Disease\"), 514 studies were found with 19 included in the review.
RESULTS: Studies focused on the impact of medication, the presence of autonomic dysfunction, and resting-state, descriptive observational studies which considered the cardiac cycle. While inconsistent, the evidence suggests that patients with PD have some systolic dysfunction, with recent research implying the presence of subclinical systolic dysfunction. From the case series, 13 participants with PD were included and collected cardiac data daily for 6 weeks. Heart rate was consistent on a weekly basis at 67-71 bpm. Mean week-by-week cardiac parameters were also consistent with the systolic time interval at 332-348 ms, isovolumic relaxation time at 92-96 ms, and isovolumic contraction time at 34-36 ms.
CONCLUSIONS: These timing intervals add valuable normative values for this patient population and the review of the literature suggests that more research is required to better understand cardiac cycle timing intervals in patients with Parkinson\'s Disease.
方法:使用搜索词(\"心动周期\"或\"超声心动图\"或\"LVET\"或\"IVCT\"或\"IVRT\"或\"LVEF\"或\"收缩功能障碍\"或\"舒张功能障碍\")和(\"帕金森病\"),共发现514项研究,其中19项纳入综述。
结果:研究集中在药物的影响,自主神经功能障碍的存在,和静息状态,考虑心动周期的描述性观察性研究。虽然不一致,证据表明PD患者有一些收缩功能障碍,最近的研究暗示存在亚临床收缩功能障碍。从案例系列中,纳入13名PD患者,每天收集心脏数据,持续6周。心率在每周67-71bpm时是一致的。每周平均心脏参数也与332-348ms的收缩时间间隔一致,等容弛豫时间为92-96ms,等体积收缩时间为34-36ms。
结论:这些时间间隔为该患者群体增加了有价值的标准值,文献综述表明,需要更多的研究来更好地了解帕金森病患者的心动周期时间间隔。