PDF(Pubmed)
Abstract：
Myelodysplastic syndrome (MDS) describes a group of bone marrow malignancies with variable morphologies and heterogeneous clinical features. The aim of this study was to systematically appraise the published clinical, laboratory, and pathologic characteristics and identify distinct clinical features of MDS in the Middle East and North Africa (MENA) region. We conducted a comprehensive search of the PubMed, Web of Science, EMBASE, and Cochrane Library databases from 2000 to 2021 to identify population-based studies of MDS epidemiology in MENA countries. Of 1935 studies, 13 independent studies published between 2000 and 2021 representing 1306 patients with MDS in the MENA region were included. There was a median of 85 (range 20 to 243) patients per study. Seven studies were performed in Asian MENA countries (732 patients, 56%) and six in North African MENA countries (574 patients, 44%). The pooled mean age was 58.4 years (SD 13.14; 12 studies), and the male-to-female ratio was 1.4. The distribution of WHO MDS subtypes was significantly different between MENA, Western, and Far East populations (n = 978 patients, p < 0.001). More patients from MENA countries were at high/very high IPSS risk than in Western and Far East populations (730 patients, p < 0.001). There were 562 patients (62.2%) with normal karyotypes and 341 (37.8%) with abnormal karyotypes. Our findings establish that MDS is prevalent within the MENA region and is more severe than in Western populations. MDS appears to be more severe with an unfavorable prognosis in the Asian MENA population than the North African MENA population.
摘要：
骨髓增生异常综合征（MDS）描述了一组具有可变形态和异质性临床特征的骨髓恶性肿瘤。这项研究的目的是系统地评估已发表的临床，实验室,和病理特征，并确定中东和北非（MENA）地区MDS的独特临床特征。我们对PubMed进行了全面搜索，WebofScience,EMBASE,和Cochrane图书馆数据库从2000年到2021年，以确定MENA国家MDS流行病学的基于人群的研究。在1935年的研究中，纳入了2000年至2021年间发表的13项独立研究，代表MENA地区的1306例MDS患者。每个研究的中位数为85名（范围为20至243名）患者。在亚洲MENA国家进行了7项研究（732名患者，56%)和6名北非MENA国家(574名患者，44%）。合并的平均年龄为58.4岁（SD13.14；12项研究），男女比例为1.4。WHOMDS亚型的分布在MENA，西方,和远东人群(n=978名患者，p<0.001)。与西方和远东人群相比，来自MENA国家的IPSS风险高/非常高的患者更多（730名患者，p<0.001)。核型正常562例(62.2%),核型异常341例(37.8%)。我们的发现证实，MDS在MENA地区普遍存在，并且比西方人群更严重。在亚洲MENA人群中，MDS似乎比北非MENA人群更严重，预后不良。
