This study aims to estimate the prevalence of HCV and analyze data related to the diagnosis and treatment-related outcomes of HCV patients with a history of intravenous drug use in the general practice setting.
A systematic review and meta-analysis in general practice.
This review included studies published in the following databases: EMBASE, PubMed, and Cochrane Central Register of Controlled Trials. Two reviewers independently extracted data in standard forms in Covidence. A meta-analysis was done using a DerSimonian and Laird random-effects model with inverse variance weighting.
A total of 20,956 patients from 440 general practices participated in the 18 selected studies. A meta-analysis of 15 studies showed a 46% (95% confidence interval (CI), 26-67%) prevalence rate of hepatitis C amongst IDUs. Genotype information was available in four studies and treatment-related outcomes in 11 studies. Overall, treatment uptake was 9%, with a cure rate of 64% (95% CI, 43-83%). However, relevant information, such as specific treatment regimens, treatment duration and doses, and patient comorbidities, was poorly documented in these studies.
The prevalence of HCV in IDUs is 46% in general practice. Only ten studies reported HCV-related treatment outcomes; however, the overall uptake rate was below 10%, with a cure rate of 64%. Likewise, the genotypic variants of HCV diagnoses, medication types, and doses were poorly reported, suggesting a need for further research into this aspect of care within this patient group to ensure optimal treatment outcomes.
目的:本研究旨在评估HCV的患病率,并分析在一般情况下有静脉用药史的HCV患者的诊断和治疗相关结果的相关数据。
方法:一般实践中的系统综述和荟萃分析。
方法:这篇综述包括发表在以下数据库中的研究:EMBASE,PubMed,和Cochrane中央控制试验登记册。两名审阅者在Covidence中以标准形式独立提取数据。使用DerSimonian和Laird随机效应模型进行了荟萃分析,该模型具有方差反加权。
结果:共有来自440个一般实践的20,956名患者参加了18个选定的研究。对15项研究的荟萃分析显示,46%(95%置信区间(CI),26-67%)注射吸毒者中丙型肝炎的患病率。4项研究提供了基因型信息,11项研究提供了治疗相关结果。总的来说,治疗吸收率为9%,治愈率为64%(95%CI,43-83%)。然而,相关信息,例如特定的治疗方案,治疗持续时间和剂量,和病人的合并症,在这些研究中记录不佳。
结论:在一般实践中,注射吸毒者中HCV的患病率为46%。只有10项研究报告了与HCV相关的治疗结果;然而,总吸收率低于10%,治愈率为64%。同样,HCV诊断的基因型变异,药物类型,剂量报告不佳,建议需要在该患者组中对这方面的护理进行进一步研究,以确保最佳的治疗结果。