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Abstract：
High-grade serous ovarian carcinoma (HGSOC) is a fatal gynecological malignancy. Somatic recombination occurring during T-cell receptor (TCR) development results in TCR diversity, and the TCR repertoire, thus produced, is associated with immune response. This study analyzed the difference in the TCR repertoire and their prognostic significance in 51 patients with HGSOC. The patient\'s clinical characteristics, gene expression pattern, TCR clonotypes, and degree of tumor-infiltrating leukocytes (TILs) were analyzed, and the patients were divided into groups depending on their recurrence pattern, tumor-infiltrating leukocyte (TIL) score, and homologous recombinant repair pathway deficiency (HRD)-associated mutations. The TCR repertoire was low in patients with recurrence and showed the expansion of eight TCR segments. Interestingly, a few genes correlated with the TCRs also showed a difference in expression according to the prognosis. Among them, seven genes were related to immune responses and KIAA1199 was up-regulated in ovarian cancer. Our study shows that the differences in the TCR repertoire in patients with ovarian cancer and their associated immune pathways could affect the prognosis of HGSOC.
摘要：
高级别浆液性卵巢癌（HGSOC）是一种致命的妇科恶性肿瘤。在T细胞受体（TCR）发育过程中发生的体细胞重组导致TCR多样性，和TCR曲目，这样产生的，与免疫反应有关。本研究分析了51例HGSOC患者TCR库的差异及其预后意义。患者的临床特征,基因表达模式，TCR克隆型，和肿瘤浸润白细胞（TIL）的程度进行了分析，患者根据他们的复发模式被分为几组，肿瘤浸润白细胞（TIL）评分，和同源重组修复途径缺陷（HRD）相关突变。复发患者的TCR库很低，并显示8个TCR片段的扩展。有趣的是,与TCR相关的一些基因也显示出根据预后的表达差异。其中,7个基因与免疫反应相关，KIAA1199在卵巢癌中表达上调。我们的研究表明，卵巢癌患者TCR库及其相关免疫通路的差异可能会影响HGSOC的预后。
