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Abstract：
Maca is a well-known biennial herb with various physiological properties, such as antioxidant activity and immune response regulation. In this study, the antioxidant, anti-inflammatory, and anti-melanogenic effects of fermented maca root extracts were investigated. The fermentation was carried out using Lactobacillus strains, such as Lactiplantibacillus plantarum subsp. plantarum, Lacticaseibacillus rhamnosus, Lacticaseibacillus casei, and Lactobacillus gasseri. In RAW 264.7 cells, the non-fermented maca root extracts increased the secretion of nitric oxide (NO), an inflammatory mediator, in a dose-dependent manner. In contrast, the fermented extracts showed considerably lower NO secretion than the non-fermented extracts at concentrations of 5% and 10%. This indicates the effective anti-inflammatory effects of fermented maca. The fermented maca root extracts also inhibited tyrosinase activity, melanin synthesis, and melanogenesis by suppressing MITF-related mechanisms. These results show that fermented maca root extracts exhibit higher anti-inflammatory and anti-melanogenesis effects than non-fermented maca root extracts. Thus, maca root extracts fermented using Lactobacillus strains have the potential to be used as an effective cosmeceutical raw material.
摘要：
玛卡是一种众所周知的两年生草本植物，具有各种生理特性，如抗氧化活性和免疫反应调节。在这项研究中,抗氧化剂，抗炎,研究了玛卡根发酵提取物的抗黑色素生成作用。发酵使用乳酸菌菌株进行，如植物乳杆菌亚种。plantarum,鼠李糖乳杆菌,干酪乳杆菌，和Gasseri乳杆菌.在RAW264.7单元格中，非发酵玛卡根提取物增加了一氧化氮（NO）的分泌，炎症介质,以剂量依赖的方式。相比之下,在浓度为5％和10％时，发酵提取物的NO分泌明显低于非发酵提取物。这表明发酵玛卡的有效抗炎作用。发酵玛卡根提取物还抑制酪氨酸酶活性，黑色素合成，和黑素生成通过抑制MITF相关机制。这些结果表明，发酵的玛卡根提取物比非发酵的玛卡根提取物表现出更高的抗炎和抗黑素生成作用。因此，使用乳酸菌菌株发酵的玛卡根提取物有可能用作有效的药妆原料。
