Abstract：
Since the end of February 2020, the world has come to a standstill due to the virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Since then, the global scientific community has explored various remedies and treatments against this virus, including natural products that have always been a choice because of their many benefits. Various known phytochemicals are well documented for their antiviral properties. Research is being carried out to discover new natural plant products or existing ones as a treatment measure for this disease. The three important targets in this regard are-papain like protease (PLpro), spike protein, and 3 chymotrypsin like proteases (3CLpro). Various docking studies are also being elucidated to identify the phytochemicals that modulate crucial proteins of the virus. The paper is simultaneously a comprehensive review that covers recent advances in the domain of the effect of various botanically derived natural products as an alternative treatment approach against Coronavirus Disease 2019 (COVID-19). Furthermore, the docking analyses revealed that rutin (inhibitor of the major protease of SARS-CoV-2), gallocatechin (e.g., interacting with 03 hydrogen bonds with a spike-like protein), lycorine (showing the best binding affinity with amino acids GLN498, THR500 and GLY446 of the spike-like protein), and quercetrin (inhabiting at its residues ASP216, PHE219, and ILE259) are promising inhibitors of SARS‑CoV‑2.Communicated by Ramaswamy H. Sarma.
摘要：
自2020年2月底以来，由于SARS-CoV-2（严重急性呼吸道综合症冠状病毒2）病毒，世界陷入停滞。从那以后,全球科学界已经探索了针对这种病毒的各种补救措施和治疗方法，包括天然产品，一直是一个选择，因为他们的许多好处。各种已知的植物化学物质的抗病毒特性已得到充分证明。正在进行研究，以发现新的天然植物产品或现有的植物产品，作为这种疾病的治疗措施。在这方面的三个重要目标是木瓜蛋白酶样蛋白酶（PLpro），刺突蛋白，和3胰凝乳蛋白酶样蛋白酶(3CLpro)。还阐明了各种对接研究，以鉴定调节病毒关键蛋白质的植物化学物质。该论文同时是一份全面的综述，涵盖了各种植物学天然产物作为2019年冠状病毒病（COVID-19）替代治疗方法的作用领域的最新进展。此外，对接分析表明，芦丁(SARS-CoV-2主要蛋白酶的抑制剂)，gallocatechin(例如，与03氢键与刺突样蛋白相互作用），lycorine（显示与刺突样蛋白的氨基酸GLN498，THR500和GLY446的最佳结合亲和力），和槲皮素（居住在其残基ASP216，PHE219和ILE259）是有希望的SARS-CoV-2抑制剂。由RamaswamyH.Sarma沟通。
