PDF(Pubmed)
Abstract：
Paracoccidioides species have always been surrounded by taxonomic uncertainties. The continuing nomenclatoral muddle was caused in part by the failure of Adolfo Lutz and Jorge Lôbo to name the etiologic agents of human paracoccidioidomycosis and Jorge Lôbo\'s diseases, respectively. Early in their history, it was postulated that the cultivable species causing systemic infections belonged in the genus Paracoccidioides, whereas the uncultivable species, causing skin disease, were not part of the genus. The taxonomy of these pathogens was further complicated when a similar skin disease with numerous yeast-like cells in infected dolphins was also reported. Due to its phenotypic similarities with that described by Jorge Lôbo in human and its uncultivable nature, it was assumed that the disease in dolphins was caused by the same fungus. Recent molecular and population genetic analysis, however, found the DNA extracted from the uncultivable yeast-like cells affecting dolphins shared common phylogenetic traits with cultivable Paracoccidioides species. The study revealed that the uncultivable pathogens comprised 2 different Paracoccidioides species, now known as P. ceti and P. loboi, correspondingly. To validate P. loboi binomial, a comprehensive historical critical review of Jorge Lôbo etiology was performed. This review showed the proposed binomial P. loboi was previously used, and, thus, a replacement name is introduced, Paracoccidioides lobogeorgii nom. nov. In addition, in this review, several cultivable human Paracoccidioides species are validated, and the generic type species, P. brasiliensis, is neotypified as the original material could not be traced.
摘要：
副球菌物种一直被分类不确定性所包围。持续的术语混乱部分是由于阿道夫·卢茨和豪尔赫·洛博未能说出人类副球藻病和豪尔赫·洛博病的病因，分别。在他们的历史早期，据推测，引起全身性感染的可培养物种属于副球菌属，而不可培养的物种，引起皮肤病,不是属的一部分。当还报道了在受感染的海豚中具有许多酵母样细胞的类似皮肤病时，这些病原体的分类学进一步复杂化。由于其与豪尔赫·洛博在人类中描述的表型相似性及其不可培养的性质，据推测，海豚的疾病是由相同的真菌引起的。最近的分子和群体遗传分析，然而,发现从影响海豚的不可培养的酵母样细胞中提取的DNA与可培养的副球菌物种具有共同的系统发育特征。研究表明，不可培养的病原体包括2种不同的副球菌物种，现在被称为P.Ceti和P.Loboi，相应地。为了验证P.loboi二项式，对豪尔赫·洛博的病因进行了全面的历史批判性审查。这篇综述显示，拟议的二项式P.loboi以前曾被使用过，and,因此，引入了替代名称，副球菌。11月。此外,在这次审查中,验证了几种可培养的人类副球菌物种，和一般类型的物种，巴西疟原虫，是新的，因为原始材料无法追踪。
