PDF(Pubmed)
Abstract：
The Buthidae family of scorpions consists of arthropods with significant medical relevance, as their venom contains a diverse range of biomolecules, including neurotoxins that selectively target ion channels in cell membranes. These ion channels play a crucial role in regulating physiological processes, and any disturbance in their activity can result in channelopathies, which can lead to various diseases such as autoimmune, cardiovascular, immunological, neurological, and neoplastic conditions. Given the importance of ion channels, scorpion peptides represent a valuable resource for developing drugs with targeted specificity for these channels. This review provides a comprehensive overview of the structure and classification of ion channels, the action of scorpion toxins on these channels, and potential avenues for future research. Overall, this review highlights the significance of scorpion venom as a promising source for discovering novel drugs with therapeutic potential for treating channelopathies.
摘要：
蝎子的Buthidae家族由具有重要医学意义的节肢动物组成，因为它们的毒液含有各种各样的生物分子，包括选择性靶向细胞膜离子通道的神经毒素。这些离子通道在调节生理过程中起着至关重要的作用,他们活动中的任何干扰都会导致信道病，这可能导致各种疾病，如自身免疫性疾病，心血管,免疫学，神经学,和肿瘤条件。考虑到离子通道的重要性,蝎子肽代表了开发对这些通道具有靶向特异性的药物的宝贵资源。这篇综述全面概述了离子通道的结构和分类，蝎子毒素在这些通道上的作用，以及未来研究的潜在途径。总的来说,这篇综述强调了蝎毒作为发现具有治疗通道病潜力的新型药物的有希望的来源的重要性。
