PDF(Pubmed)
Abstract：
The global emergence of methicillin-resistant Staphylococcus aureus (MRSA) that unsusceptible to a wide selection of antimicrobial agents and any newly introduced antimicrobial over the past decades has triggered more extensive holistic measures to put an end to this situation. Molecular surveillance of MRSA clones is important to understand their evolutionary dynamics for investigating outbreaks, propagating precautionary measures, as well as planning for appropriate treatment. This review includes peer-reviewed reports on the molecular characterisation of clinical Staphylococcus aureus isolates within Malaysian hospitals from year 2008 to 2020. This work highlights the molecular clones of hospital-acquired MRSA (HA-MRSA) and community-acquired MRSA (CA-MRSA) isolates from Malaysian hospitals, with description on their ever-changing pattern. Among HA-MRSA, the ST22-t032-SCCmec IV MRSA clone was reported to supplant the previous dominating clone, ST239-t037-SCCmec III. Meanwhile, ST30, ST772, ST6 and ST22 were repeatedly detected in CA-MRSA, however, none of the strains became predominant. Future in-depth study on molecular epidemiology of MRSA clone is essential for the investigation of the extent of the clonal shift, especially in Malaysia.
摘要：
耐甲氧西林金黄色葡萄球菌（MRSA）的全球出现，对广泛的抗微生物剂和过去几十年中任何新引入的抗微生物剂都不敏感，这引发了更广泛的整体措施来结束这种情况。MRSA克隆的分子监测对于了解它们的进化动力学对于调查爆发非常重要，宣传预防措施，以及计划适当的治疗。这篇综述包括2008年至2020年马来西亚医院临床金黄色葡萄球菌分离株分子特征的同行评审报告。这项工作重点介绍了来自马来西亚医院的医院获得性MRSA（HA-MRSA）和社区获得性MRSA（CA-MRSA）分离株的分子克隆，描述他们不断变化的模式。在HA-MRSA中，据报道，ST22-t032-SCCmecIVMRSA克隆取代了以前的主要克隆，ST239-t037-SCCmecIII.同时,ST30、ST772、ST6和ST22在CA-MRSA中反复检测，然而,没有一个菌株成为主要菌株。未来对MRSA克隆分子流行病学的深入研究对于研究克隆转移的程度至关重要,尤其是在马来西亚。
